NCT07043790Completed
Radical Cystectomy Versus Tri-Modal Therapy for Treatment of cT2N0M0 Urinary Bladder Transitional Cell Carcinoma
Source: ClinicalTrials.gov · Last updated 30 Jul 2025
Brief summary (registry, in English)
the aim of this study is to compare the oncological outcome of trimodal therapy with bladder preservation using maximal resection with chemoradiation versus the standard radical cystectomy for muscle invasive transitional cell carcinoma of urinary bladder.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 73 (actual)
- First submitted
- 21 Jun 2025
- Start date
- 1 Apr 2021
- Primary completion date
- 3 Apr 2025
- Lead sponsor
- Ain Shams University
- Diseases
- Bladder cancer
- NCT number
- NCT07043790
What you commit to
- Study type: Interventional
- Participants enrolled: 73
- From 1 Apr 2021 to the primary completion date, 3 Apr 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients unfit for surgery.
- Patients unfit for chemotherapy or radiotherapy.
- Prior chemotherapy or radiotherapy for bladder cancer.
Other illness
- Non-TCC histology of bladder cancer.
- High-grade non-muscle invasive bladder cancer (NMIBC).
Other
- Evidence of significant nodal involvement on imaging.
- Presence of carcinoma in situ (CIS).
- Hydronephrosis attributed to the bladder tumor.
- TCC with atypical histological variants including:
- Micropapillary,
- Plasmacytoid,
- Anaplastic, or
- Sarcomatoid variants.
- Refusal to undergo randomization.
Who the study is looking for
- Adults of any gender, aged 18 years or older.
- Histologically confirmed urothelial (transitional cell) carcinoma (TCC) of the urinary bladder, clinical stage T2N0M0, diagnosed through:
- Imaging (CT or MRI).
- Cystoscopy.
- Biopsy and histopathological examination of the tumor.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ain Shams University Coordinator of this site? Confirm its status | Cairo | Egypt | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.