NCT07044661Not yet recruiting
Effect of Bilateral vs. Unilateral Alveolar Recruitment on Gas Exchange in Lung Resection
Source: ClinicalTrials.gov · Last updated 1 Jul 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
"One-lung ventilation (OLV) is an essential technique during thoracic surgery but preventing atelectasis during OLV remains a key challenge in thoracic anesthesia. Several previous randomized controlled trials have demonstrated that alveolar recruitment maneuvers (ARMs) can significantly reduce driving pressure, peak airway pressure, plateau pressure, and anatomical dead space. However, the optimal method for implementing ARMs has not yet been standardized, as the timing and target of ARM application vary among studies. Some protocols involve applying ARMs to both lungs immediately prior to the initiation of OLV (bilateral ARM), while others apply ARMs solely to the non-operative lung after OLV has begun (unilateral ARM). Bilateral ARM may provide prolonged improvement in gas exchange but carry the risk of insufficient collapse of the operative lung. Conversely, unilateral ARM may facilitate better collapse of the operative lung compared to bilateral ARMs, though potentially at the expense of gas exchange. To date, no study has directly compared these two approaches. This study aims to compare and evaluate the effects of bilateral versus unilateral ARM performed immediately prior to thoracic incision on intraoperative gas exchange and the incidence of intraoperative and postoperative complications."
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 198 (estimated)
- First submitted
- 23 Jun 2025
- Start date
- Jul 2025
- Primary completion date
- Apr 2027
- Lead sponsor
- Yonsei University
- Diseases
- Lung cancer
- NCT number
- NCT07044661
What you commit to
- Study type: Interventional
- Planned participants: 198
- From Jul 2025 to the primary completion date, Apr 2027
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- History of pneumothorax or radiologic evidence of pulmonary blebs or bullae prior to surgery.
- Patients receiving supplemental oxygen therapy or mechanical ventilation prior to surgery.
- Dropout Criteria
- Surgery is canceled or converted to an open thoracotomy or another surgical approach.
Other illness
- Diagnosis of heart failure.
Other
- Anticipated duration of one-lung ventilation (OLV) less than 1 hour.
- Actual duration of OLV less than 1 hour.
- Inability to maintain peripheral oxygen saturation ≥90% despite adjustments in inspired oxygen fraction.
- Inability to maintain ventilator settings due to extensive pulmonary adhesions.
Who the study is looking for
- -Adult patients aged 20 to 80 years scheduled for thoracoscopic lung resection.
- American Society of Anesthesiologists (ASA) physical status classification of I to III.
Age in the registry: 20 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Severance Hospital, Yonsei University Health System Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
| Severance hospital Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.