NCT07045207Not yet recruiting
Evaluating AI and Human Expert Decisions in Colorectal Cancer
Comparison of Large Language Models and Expert Multidisciplinary Team Decisions in Colorectal Cancer
Source: ClinicalTrials.gov · Last updated 1 Jul 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The goal of this observational study is to evaluate the decision-making consistency between large language models (LLMs) and expert multidisciplinary teams (MDTs) in adult patients diagnosed with colorectal cancer who underwent MDT consultation between January 2023 and December 2024. The main questions it aims to answer are: How consistent are the treatment decisions generated by LLMs compared to actual MDT decisions? Do different LLMs (e.g., ChatGPT, DeepSeek) show varying levels of agreement with expert recommendations? What clinical factors contribute to differences between AI-generated and human expert decisions? Researchers will compare the AI-generated treatment recommendations with real-world MDT decisions using anonymized patient records to see if LLMs can reliably support clinical decision-making in oncology. Participants will: Have their de-identified clinical data (e.g., imaging, pathology, MDT notes) processed through several LLMs Not be contacted or receive any interventions, as this is a retrospective study using existing clinical records only.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 1500 (estimated)
- First submitted
- 22 Jun 2025
- Start date
- 1 Jul 2025
- Primary completion date
- 1 Jun 2026
- Lead sponsor
- Peking University Cancer Hospital & Institute
- Diseases
- Colorectal cancer, Childhood cancers
- NCT number
- NCT07045207
What you commit to
- Study type: Observational
- Planned participants: 1500
- From 1 Jul 2025 to the primary completion date, 1 Jun 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Incomplete or missing medical records related to MDT decision-making
- MDT consultations conducted for non-oncologic purposes (e.g., hernia evaluation, stoma planning)
- Missing critical clinical data such as imaging or pathology reports
- Duplicate or conflicting records that prevent reliable data analysis
Who the study is looking for
- Patients with a histologically confirmed diagnosis of colorectal cancer
- Patients who received multidisciplinary team (MDT) consultation at Peking University Cancer Hospital between January 1, 2023 and December 31, 2024
- Availability of complete clinical records, including(MDT consultation notes, CT or MRI imaging reports, Pathology reports, Outpatient or inpatient medical summaries)
Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Peking University Cancer Hospital Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.