NCT07046676RecruitingPhase 4
Pharmacogenetics-Based Study on Individualized Use of Sodium Valproate
Research on the Application of Sodium Valproate Personalized Medication Based on Pharmacogenetics
Source: ClinicalTrials.gov · Last updated 10 Jul 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Sodium valproate (VPA) is a first-line prescription drug widely used in the treatment of epilepsy. However, in clinical applications, it has been found that there is a large individual variation in the blood concentration of VPA. In particular, excessively high blood drug concentrations can lead to various side effects, especially hepatotoxicity. Blood drug concentration monitoring can reduce the toxic and side effects of VPA to a certain extent and improve its effectiveness, but it is too cumbersome. A large number of studies have shown that the efficacy and toxic side effects of VPA are closely related to its in vivo metabolism process. The in vivo metabolism of VPA is affected by many factors, and the genetic polymorphism of drug-metabolizing enzymes is an important factor leading to differences in blood drug concentrations and affecting the dosage of VPA. The three products generated by the biotransformation of VPA by CYP450 enzymes are all related to hepatotoxicity. The formation of 4-ene-VPA is largely catalyzed by CYP2C9 and CYP2A6. Mutations in the CYP2A6 gene may be related to VPA hepatotoxicity, but there is a lack of further direct evidence. 50% of VPA in the body is acidified and metabolized into inactive products by uridine diphosphate glucuronosyltransferase (UGT) through phase II conjugation reactions. However, there is evidence that the genetic polymorphism of UGT can significantly affect the blood drug concentration of metformin. Based on the above research, we selected CYP2A6, UGT1A6, etc. as candidate genes, and studied the impact of genetic polymorphisms on the individual differences of sodium valproate through association analysis, with the hope of establishing a genetic model for optimal dosage and providing new strategies for the individualized use of VPA.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 312 (estimated)
- First submitted
- 23 Jun 2025
- Start date
- 1 Dec 2022
- Primary completion date
- 30 Dec 2025
- Lead sponsor
- The First Affiliated Hospital of University of South China
- Diseases
- Epilepsy
- NCT number
- NCT07046676
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 312
- From 1 Dec 2022 to the primary completion date, 30 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients with incomplete data, poor compliance, and those whose blood drug concentration was not measured at the correct concentration
Other illness
- Patients with major respiratory, gastrointestinal, liver, kidney or other serious diseases
- Patients using valproic acid solely for epilepsy prevention
Age
- Patients over 65 years old and in the 1CU
Other
- Patients who have used valproic acid for more than 5 days but have frequently changed the dosage form during the process
Who the study is looking for
- Patients diagnosed with epilepsy (primary epilepsy, secondary epilepsy) and with complete clinical data
- Regular use of valproic acid sodium for at least 5 days (with blood drug concentration reaching a steady state) and strong medication compliance
- Patients using combined anti-epileptic drugs or using valproic acid sodium alone
- Patients without significant liver or kidney dysfunction, and not in the pregnancy period
Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The First Affiliated Hospital of University of South China Coordinator of this site? Confirm its status | Hengyang | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.