NCT07047495Recruiting
Personalization of External Beam Radiation Therapy in Localised Tumours
MINIONS - Patient-specific Microstructural and radIobiological Model for persoNalised External Beam radiatION Therapy in Localised tumourS
Source: ClinicalTrials.gov · Last updated 2 Jul 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The study will include the prospective acquisition of optimized MR imaging data of prostate and breast patients treated with radiotherapy (RT). Within the prospective study, biological specimens from patients undergoing in-room biopsy before RT, will be collected. Histological evaluation and cell culture (and organoid preparation) will be conducted, and samples/organoids will be irradiated with RT for biological validation.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 35 (estimated)
- First submitted
- 24 Jun 2025
- Start date
- 1 Jul 2025
- Primary completion date
- 31 Jul 2030
- Lead sponsor
- European Institute of Oncology
- Diseases
- Prostate cancer
- NCT number
- NCT07047495
What you commit to
- Study type: Observational
- Planned participants: 35
- From 1 Jul 2025 to the primary completion date, 31 Jul 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Neoadjuvant therapy
- previous radiotherapy to the chest
- No previous thoracic radiotherapy
Other illness
- Exclusion criteria for prostate patients:
- Nodule involvement and metastasis (cN1 and/or cM1)
- Concomitant inflammation of the intestine
- Significant systemic diseases or ongoing oral anticoagulant therapy
- Non-compliance of dose constraints in the treatment plan
- Previous invasive cancer, unless the patient has had no disease for at least 3 years
- Mental disorders that cannot ensure valid informed consent
- Bilateral breast cancer
- autoimmune connective tissue diseases
- Mental disorders that cannot ensure valid informed consent
Other
- Histology other than non-special histotype and non-epithelial tumors (sarcoma, lymphoma)
- Male sex
- High-risk mutation carrier patients
- synchronous distant metastases
Who the study is looking for
- Unifocal infiltrating ductal breast carcinoma, non-special histotype
- clinical stage T1-T2,N0
- No contraindications to MRI, or metal joint prostheses from knee to shoulder included, or femoral stent.
- Patients aged \>18 years
- Good general condition (ECOG 0-2)
- Expected active treatment (crioablation or surgery or radiotherapy ).
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| European Institute of Oncology Coordinator of this site? Confirm its status | Milan | Italy | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.