NCT07047534Completed
EEG-Triggered rTMS and Group Therapy for Adolescents With Depression and Self-Harm
Real-time EEG-Triggered Transcranial Magnetic Stimulation Combined With Group Therapy for Adolescents With Depression and Self-Harm Behavior: A Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 2 Jul 2025
Brief summary (registry, in English)
This randomized controlled trial aims to evaluate the efficacy of real-time EEG-triggered repetitive transcranial magnetic stimulation (rTMS) combined with group therapy versus rTMS alone in adolescents (aged 12-18 years) diagnosed with depression and exhibiting recent self-harm behavior. The primary outcome is the change in depression severity at 4 weeks.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 160 (actual)
- First submitted
- 24 Jun 2025
- Start date
- 1 Jun 2024
- Primary completion date
- 31 Dec 2024
- Lead sponsor
- The First Hospital of Hebei Medical University
- Diseases
- Depression
- NCT number
- NCT07047534
What you commit to
- Study type: Interventional
- Participants enrolled: 160
- From 1 Jun 2024 to the primary completion date, 31 Dec 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current use of electroconvulsive therapy;
Other illness
- Comorbid psychotic disorders (e.g., schizophrenia), bipolar disorder, or autism spectrum disorder;
- History of neurological conditions (e.g., epilepsy, traumatic brain injury);
Other
- Refusal to provide informed consent.
Who the study is looking for
- Age 12-18 years;
- Diagnosis of major depressive disorder (MDD) according to the International Classification of Diseases, 10th Revision (ICD-10 F32);
- Documented self-harm behavior within 2 weeks prior to enrollment (defined as deliberate self-injury without suicidal intent, e.g., cutting, burning);
- Hamilton Depression Rating Scale (HAMD-24) score ≥17 at baseline;
- Ability to complete self-report measures and participate in group therapy.
Age in the registry: 12 years to 18 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The First Hospital of Hebei Medical University Coordinator of this site? Confirm its status | Shijiazhuang | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.