NCT07048509Recruiting
Difference in Acute Responses of Vascular Function to Moderate-intensity and High-intensity Interval Training in Healthy and Prehypertensive Individuals
Source: ClinicalTrials.gov · Last updated 19 Oct 2026
Brief summary (registry, in English)
In this study, the investigators will evaluate acute changes in vascular function measures after moderate-intensity continuous and high-intensity interval exercise in healthy and prehypertensive individuals. Participants will be subjected to three separate visits: control condition (30 min rest), moderate-intensity continuous exercise, and high-intensity interval exercise. The investigators will measure aerobic capacity using a cardiopulmonary exercise test (CPET) using indirect gas-exchange to derive subsequent exercise intensity and maximal oxygen uptake. The investigators will evaluate different measures of vascular function (Pulse-wave velocity, Flow-mediated slowing, microvascular function) before and after each condition. The study will involve two groups of participants: healthy individuals and prehypertensive individuals. The investigators aim to establish the reliability and validity of less-established methods of vascular function assessment (flow-mediated slowing and microvascular function) against established measures (pulse-wave velocity). The acute response of vascular function to different exercise intensities has not yet been thoroughly researched using the aforementioned measures in individuals with similar characteristics to the proposed study cohort.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 45 (estimated)
- First submitted
- 20 Jun 2025
- Start date
- 24 Jun 2025
- Primary completion date
- Dec 2026
- Lead sponsor
- University of Ljubljana
- Diseases
- High blood pressure
- NCT number
- NCT07048509
What you commit to
- Study type: Interventional
- Planned participants: 45
- From 24 Jun 2025 to the primary completion date, Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prescribed medication
Other illness
- Chronic diseases
Other
- Blood pressure out of the optimal range (normotensives)
- High level of phyisical activity (moderate or high active according to GPAQ)
- Hypotension
- Lower extremity injury in the last six months
- Menopause
- Absence of normal menstrual cycle
- Pregnancy
- Smoking
Who the study is looking for
- Normotensive participants inclusion criteria:
- 18 - 50 years of age, BMI \< 30, blood pressure (BP) within the optimal range according to the latest ESH guidelines (\< 120 mmHg systolic and/or \< 80 mmHg diastolic BP)
- Sedentary or low active according to the Global Physical Activity Questionnaire (GPAQ) (Armstrong \& Bull, 2006; Lim et al., 2012)
- No prescribed medication and absence of chronic diseases
- 18 - 50 years of age, BMI \< 30
- Diagnosed prehypertension by a clinican from the Hypertension clinic, University clinical centre of Ljubljana using established criteria
- Sedentary or low or moderately active according to the Global Physical Activity Questionnaire (GPAQ)
- No prescribed medication and absence of chronic diseases
Age in the registry: 18 years to 50 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Ljubljana, Faculty of sport Coordinator of this site? Confirm its status | Ljubljana | Slovenia | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.