NCT07049783Completed
Examining the Circadian Timing Effects of the Hypotensive Response to Exercise
Source: ClinicalTrials.gov · Last updated 22 Oct 2026
Brief summary (registry, in English)
The goal of this study is to learn how exercise timing affects blood pressure in adults with elevated or high blood pressure. Exercise can influence the body's natural 24-hour rhythms, including blood pressure patterns. A single exercise session can lower blood pressure for up to 24 hours, but it is not fully understood how the time-of-day for exercise affects this response. The main question this study aims to answer is: • When the same participant exercises at different times of day (morning, afternoon, or evening), how does this affect the participant's blood pressure over the next 24 hours? Participants will: * Undergo an in-lab assessment of individual biological rhythm that will indicate the clock-time for an individual's biological night * Complete 3 supervised treadmill exercise sessions * 1 in the biological morning (biological night + 10 hours) * 1 in the biological afternoon (biological night + 15 hours) * 1 in the biological evening (biological night + 20 hours) * Complete a 24-hour blood pressure assessment before and after each exercise session
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 8 (actual)
- First submitted
- 25 Jun 2025
- Start date
- Jul 2025
- Primary completion date
- Oct 2026
- Lead sponsor
- Freda Patterson
- Diseases
- High blood pressure
- NCT number
- NCT07049783
What you commit to
- Study type: Interventional
- Participants enrolled: 8
- From Jul 2025 to the primary completion date, Oct 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Alcohol or drug dependence
- Self-reported use of sleep medications/supplements (e.g., melatonin)
- Self-reported use of medications influencing vascular physiology (e.g., antihypertensive medications, weight loss medications)
Other illness
- Diagnosis or history of chronic or autoimmune disease (i.e., cardiovascular, metabolic, renal, endocrine, cancer)
- Diagnosis or history of sleep disorder (i.e., obstructive sleep apnea, insomnia, restless leg syndrome)
- Elevated risk for sleep disorders
- Normotensive (blood pressure less than 120/80 mmHg) or stage 2+ hypertension (blood pressure greater than or equal to 140/90 mmHg)
Other
- Elevated risk for clinical depression
- Body mass index less than 18.5 or greater than 35 kg/m2
- Highly physically active (greater than or equal to 300 minutes moderate-to-vigorous physical activity per week)
- Currently pregnant or breastfeeding
- Current tobacco use (greater than or equal to 1 cigarette in the past month)
- Nighttime or rotating shift work within the last 3 months
- Contraindications to aerobic exercise
Who the study is looking for
- 18-39 Years old
- Resting blood pressure greater than or equal to 120/80 mmHg or less than 140/90 mmHg
Age in the registry: 18 years to 39 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Delaware Coordinator of this site? Confirm its status | Newark | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.