NCT07050485Enrolling by invitation
Postbiotics for Mitigation of Postoperative Dysbiosis in Gastrointestinal Cancer Surgery
Postbiotics for Mitigation of Postoperative Dysbiosis in Gastrointestinal Cancer Surgery: A Randomized, Single-blinded, Placebo-controlled Trial (REPOT)
Source: ClinicalTrials.gov · Last updated 29 Dec 2025
Brief summary (registry, in English)
To measure the efficacy of postbiotic supplements in mitigating the gut dysbiosis induced by colon cancer surgery. Efficacy in mitigating dysbiosis will be measured by the change in fecal Shannon Diversity Index (SDI) within patients from the baseline sample to various postoperative timepoints. Mean change in SDI from baseline will be compared between groups at 2 weeks postoperative
- Status (registry)
- Enrolling by invitation
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- First submitted
- 20 Jun 2025
- Start date
- 15 Jul 2025
- Primary completion date
- 30 Apr 2026
- Lead sponsor
- University of South Florida
- Diseases
- Colorectal cancer
- NCT number
- NCT07050485
What you commit to
- Study type: Interventional
- Planned participants: 30
- From 15 Jul 2025 to the primary completion date, 30 Apr 2026
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Exposed to antibiotics in the 3 months prior to enrollment (per patient-provided history)
- Prior use of any investigational drug in the preceding 6 months prior to enrollment
- Emergency surgery
Other illness
- Patients with inflammatory bowel disease
- Inability to give consent due to a mental condition that makes the participant unable to understand the study's nature, scope, and possible consequences.
- Known allergy or intolerance to ingredients commonly used in gummy supplements (e.g., gelatin, corn syrup, artificial colors, or natural flavors)
Other
- Unlikely to comply with protocol as determined by Investigator
- Prisoners
Who the study is looking for
- Recently diagnosed with nonmetastatic GI cancer, including but not limited to small bowel, colon, rectal, pancreatic, gastric, or hepatic malignancies, and scheduled for an elective laparoscopic curative-intent surgical resection in 6 days
- Able and willing to provide informed consent
- Age 18 years and above
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of South Florida Coordinator of this site? Confirm its status | Tampa | United States | Unknown status |
| Tampa General Hospital Coordinator of this site? Confirm its status | Tampa | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.