NCT07054060Recruiting
Endarterectomy Versus Stenting in Patients With Symptomatic Severe Carotid Stenosis - 2
Source: ClinicalTrials.gov · Last updated 24 Jul 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Carotid stenosis caused by atherosclerosis is a significant risk factor for ischemic stroke, accounting for up to 15% of all strokes and transient ischemic attacks. Randomized clinical trials (RCTs) have demonstrated the benefits of carotid endarterectomy (CEA) in reducing stroke risk in patients with severe symptomatic carotid stenosis. Carotid artery stenting (CAS) has been developed as an alternative to CEA, offering several potential advantages, such as avoiding local surgical complications. However, unlike CEA, CAS has not been compared to medical therapy in RCTs for symptomatic carotid stenosis.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 600 (estimated)
- First submitted
- 13 May 2025
- Start date
- 16 Jul 2025
- Primary completion date
- 16 Mar 2028
- Lead sponsor
- Centre Hospitalier St Anne
- Diseases
- Stroke
- NCT number
- NCT07054060
What you commit to
- Study type: Interventional
- Planned participants: 600
- From 16 Jul 2025 to the primary completion date, 16 Mar 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous revascularization of the symptomatic carotid stenosis
- Contraindication to dual antiplatelet therapy
- Percutaneaous or surgical intervention within 30 days before or after the study procedure
Other illness
- Nonatherosclerotic carotid disease
- History of bleeding disorder
- Unstable angina
Other
- Patients unwilling or unable to participate in follow-up for whatever reason
- Preexisting disability (Modified Rankin Score ≥ 3)
- Severe tandem lesions
- Contraindication to MRI
- Life expectancy of less than 2 years
- Stenotic lesion on arterial workup appeared as not a factor in the selection
Who the study is looking for
- Patient age 18 years or over
- Hemispheric or retinal transient ischemic attack or a non-disabling stroke (or retinal infarct) within 15 days before enrolment
- Stenosis of 50% to 99% in the symptomatic carotid artery (NASCET method) for whom revascularisation is decided according to guidelines
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Centre Hospitalier Sainte-Anne Coordinator of this site? Confirm its status | Paris | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.