NCT07054424Recruiting
Repetitive Transcranial Magnetic Stimulation Combined With Bimanual Therapy for Upper Limb Stroke Rehabilitation
Development of Repetitive Transcranial Magnetic Stimulation (rTMS) Combined With Machine-assisted Bimanual Therapy (BT) in Upper Limb Rehabilitation
Source: ClinicalTrials.gov · Last updated 11 Jun 2026
Brief summary (registry, in English)
The goal of this clinical trial is to evaluate whether combining repetitive transcranial magnetic stimulation (rTMS) with machine-assisted bimanual therapy (BT) can improve upper limb function in stroke patients. The participants will be individuals aged 40-80 years who have experienced a first-time ischemic or hemorrhagic stroke. The main questions it aims to answer are: * Does the combined therapy enhance motor recovery compared to traditional rehabilitation methods? * Are changes in brain activity associated with improvements in upper limb function? Participants will be randomly assigned to different groups and will: * Receive rTMS stimulation on specific areas of the brain to modulate neural activity, * Perform machine-assisted bimanual exercises to promote motor skills, and * Undergo assessments before, immediately after, and during follow-up periods to measure functional improvements.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 54 (estimated)
- First submitted
- 8 Jun 2025
- Start date
- 5 Jun 2025
- Primary completion date
- 31 Jul 2027
- Lead sponsor
- Chang Gung Memorial Hospital
- Diseases
- Stroke
- NCT number
- NCT07054424
What you commit to
- Study type: Interventional
- Planned participants: 54
- From 5 Jun 2025 to the primary completion date, 31 Jul 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Currently using medications that lower the seizure threshold;
- Subjects taking antidepressants who cannot discontinue the medication;
Other illness
- A history of epilepsy or family history of epilepsy;
- Co-existing neurological diseases (such as multiple sclerosis, other neurodegenerative diseases, meningitis, brain abscess, or meningioma);
- Subjects with sleep disorders during rTMS treatment;
- Subjects with cerebellar stroke or brainstem stroke;
- Cerebral ischemic disorders resulting from traumatic brain injury;
- History of bleeding tendency and other conditions affecting upper limb function, such as myasthenia gravis, systemic immune neuropathy, severe epilepsy, endocrine system disorders, wearers of external or internal cardiac pacemakers, individuals with metallic implants or orthopedic devices;
- Co-existing severe heart, liver, kidney dysfunction, or other serious physical illnesses;
- Subjects with impaired consciousness who cannot cooperate with examinations or treatments, such as those with mental disorders, or those with intellectual or cognitive impairments, severe dementia;
- Co-existing severe liver, kidney, or hematological disorders;
- Skin disease (e.g., pressure ulcers, trauma, cellulitis, etc.).
Other
- Presence of suicidal tendencies;
- Pregnant or planning to become pregnant;
- Subjects with uncontrollable migraines caused by elevated intracranial pressure;
- Transient ischemic attacks (TIAs);
- Presence of implanted electronic devices in the body;
- Special vulnerable populations;
Who the study is looking for
- Age 40-80 years;
- First-onset stroke patients;
- Patients diagnosed with cerebral infarction or hemorrhage through CT or MRI;
- Signed informed consent form by the patient and their family;
- Stable physiological parameters;
- Stroke occurred within the last 12 months;
- Patients with unilateral hand function impairment caused by the stroke;
- Upper limb muscle tone (Modified Ashworth Scale, MAS) less than 3 points;
- Able to follow two-step commands.
Age in the registry: 40 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, Taiwan Coordinator of this site? Confirm its status | Taoyuan | Taiwan | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.