NCT07055542Recruiting
Creating A Risk Assessment Tool for Thunderstorm Asthma: the CARISTA Study
Creating A RIsk Assessment Biomarker Tool to Prevent Seasonal and Thunderstorm Asthma: The CARISTA Study
Source: ClinicalTrials.gov · Last updated 6 May 2026
Brief summary (registry, in English)
Thunderstorm asthma is a recurring public health emergency in South-Eastern Australia which occurs in springtime. The major identified risk factors for thunderstorm asthma is hay fever and allergy to ryegrass pollen. The goal of the CARISTA study is to identify the risk of springtime allergic and thunderstorm asthma in allergic adults living in South-Eastern Australia. To do this the investigators will recruit 530 people who have hay fever and test them for allergy to ryegrass pollen and undertake simple lung function testing. The investigators will ask study participants to complete a customised symptom tracker over the springtime pollen season for 2 consecutive years. The outcome the investigators are looking for is an asthma exacerbation or worsening asthma symptoms. This study will enable the investigators to identify indicators (biomarkers) of severe and moderate asthma exacerbations in order to identify those at risk of thunderstorm and seasonal asthma so protective treatments and strategies can be advised.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 530 (estimated)
- First submitted
- 10 Jun 2025
- Start date
- 27 Aug 2025
- Primary completion date
- 31 Dec 2029
- Lead sponsor
- University of Melbourne
- Diseases
- Asthma
- NCT number
- NCT07055542
What you commit to
- Study type: Interventional
- Planned participants: 530
- From 27 Aug 2025 to the primary completion date, 31 Dec 2029
- 6 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Individuals who do not consent to lung function testing and blood sample collection - Individuals with unstable asthma (FEV1 by spirometry less than 70% predicted), a recent exacerbation or change of asthma preventive medication use (within one month) would be excluded, although re-screening would be permitted after one month, time permitting.
- Individuals with severe asthma requiring the use of continuous oral corticosteroids or biological medication for severe asthma.
Other illness
- Individuals who do not suffer from symptoms of seasonal allergic rhinitis
- The presence of any medical illness, such as cardiac disease, pre-existing illness or immunomodulatory therapy that, in the opinion of the Investigators, would compromise participant safety or the derivation of biomarkers during the study.
Other
- Individuals unable to provide informed consent
Who the study is looking for
- Consenting adults aged 18 to 70 years with seasonal allergic rhinitis
- willing to undertake:
- Lung function testing
- Blood sample collection for risk factor identification, -Prospectively logging their symptoms and medications through the springtime season using the CARISTA symptom monitoring platform . -
Age in the registry: 18 years to 70 years · Sex: All · Accepts healthy volunteers
Sites (6)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Albury-Wodonga Health Coordinator of this site? Confirm its status | Albury | Australia | Recruiting |
| Eastern Health Coordinator of this site? Confirm its status | Box Hill | Australia | Recruiting |
| Monash Health Coordinator of this site? Confirm its status | Clayton | Australia | Recruiting |
| Austin Health Coordinator of this site? Confirm its status | Heidelberg | Australia | Recruiting |
| The Alfred Hospital Coordinator of this site? Confirm its status | Melbourne | Australia | Recruiting |
| The Royal Melbourne Hospital Coordinator of this site? Confirm its status | Parkville | Australia | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.