NCT07060391Not yet recruitingPhase 3
A Prospective Multicenter RCT Study of Deep Jugular Lymphovenous Anastomosis in the Treatment of Alzheimer's Disease
Source: ClinicalTrials.gov · Last updated 11 Jul 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This research aims to observe the efficacy and safety of surgery compared with traditional medical treatment for moderate to severe dementia in Alzheimer's disease. This is a prospective multicenter RCT clinical research, involving a total of 3 research centers.Patients diagnosed with Alzheimer's disease accompanied by moderate to severe cognitive dysfunction in these three hospitals from January 2025 to January 2027 were included. This research is expected to recruit a total of 186 patients with moderate to severe Alzheimer's disease.93patients received conventional medical treatment, Deep cervical lymphatic-venous anastomosis was performed in 93 patients.Comprehensively evaluate the efficacy and safety of the patients within 48 weeks after treatment.
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 186 (estimated)
- First submitted
- 22 Jun 2025
- Start date
- 31 Jul 2025
- Primary completion date
- 31 Jan 2027
- Lead sponsor
- Shanghai Jiao Tong University School of Medicine
- Diseases
- Alzheimer disease
- NCT number
- NCT07060391
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 186
- From 31 Jul 2025 to the primary completion date, 31 Jan 2027
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients who cannot tolerate surgery.
- Patients who cannot tolerate donepezil drug treatment.
Other illness
- A history of radiotherapy or surgery for the head and neck.
- Patients with other diseases that affect cognitive function.
Other
- Patients or their families with poor compliance who cannot strictly follow the rules.
Who the study is looking for
- The patient was clinically diagnosed with Alzheimer's disease and had a moderate to severe cognitive function score.
- Age: 30-80 years old.
- Gender is not limited.
- The patient or their family members authorize their willingness to participate in this clinical trial and sign the informed consent form.
- no contraindications for surgery.
Age in the registry: 30 years to 80 years · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.