NCT07062172Recruiting
Lung Cancer Screening of Family Members of Patients With Mutation-Driven Lung Cancer
Source: ClinicalTrials.gov · Last updated 14 Jul 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This is a single-armed screening research study which screens immediate family member of lung cancer patients with a driver mutation to see if lung cancer can be inherited and whether researchers can find lung cancer early. Immediate family members of lung cancer patients will be 40-80 years old and screened using a low dose CT scan.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 1753 (estimated)
- First submitted
- 2 Jul 2025
- Start date
- 8 May 2025
- Primary completion date
- 31 Dec 2027
- Lead sponsor
- University of California, Irvine
- Diseases
- Lung cancer
- NCT number
- NCT07062172
What you commit to
- Study type: Interventional
- Planned participants: 1753
- From 8 May 2025 to the primary completion date, 31 Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous history of lung cancers.
Other illness
- Symptoms suggestive of presence of current lung cancer, including (but not limited to): unexplained weight loss of over 15 pounds within the last 12 months or unexplained hemoptysis.
- History of any type of cancer within 5 years, with the exception of in situ carcinomas and non-melanoma skin cancers (if excised).
Other
- There are no exclusion criteria for Cohort A.
- Cohort B:
- Pregnant at time of enrollment.
- Current smoker.
- Smoked ≥ 20 pack years.
- Had a chest CT scan within 1 year of study entry.
Who the study is looking for
- Current diagnosis of lung cancer with a driver mutation.
- Known driver mutation (e.g. via NGS, PCR, IHC, FISH, RT-PCR etc.)
- Able and willing to give informed consent.
- Able and willing to complete the screening questionnaire.
- Cohort A:
- Age 40 - 80.
- Must have a first degree relative (mother, father, sibling, biological child) eligible for Cohort A. Note: Multiple first degree relatives of a Cohort A eligible participant may be approached for participation into the trial.
- Smoked \< 20 pack years; a. Pack years = numbers of packs per day × number of years smoked; b. One pack year is the equivalent of smoking an average of 20 cigarettes (1 pack) per day for a year.
- Be able to undergo a low dose chest CT scan.
- If an upper respiratory infection (pneumonia, COVID19, flu, etc.) occurred in the last 3 months, this infection must have resolved by time of enrollment.
- Able and willing to provide informed consent.
- Able and willing to comply with the protocol requirements
- Cohort B:
Criteria the registry did not label
- Cohort A:
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Chao Family Comprehensive Cancer Center, University of California, Irvine Coordinator of this site? Confirm its status | Orange | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.