NCT07062289Not yet recruiting
Endoscopic Ultrasound-guided Measurement of Portal Vein Pressure Gradient
Study on the Measurement of Portal Vein Pressure Gradient Guided by Endoscopic Ultrasound Based on Portal Vein Thrombosis and Portal Hypertension
Source: ClinicalTrials.gov · Last updated 14 Jul 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This study aims to evaluate the accuracy and safety of a novel endoscopic ultrasound-guided portal pressure gradient (EUS-PPG) measurement technique in 42 adults with liver cirrhosis and portal vein thrombosis (blood clots in the liver's main vein), a condition where current standard testing (HVPG) fails to provide reliable pressure readings. Participants will undergo both EUS-PPG (using a specialized needle under ultrasound guidance) and HVPG procedures to compare results; EUS-PPG will be performed under general anesthesia in a left-side lying position-an innovative approach-while also enabling immediate endoscopic treatment of bleeding veins if detected during the same session. The primary goals are to validate EUS-PPG's safety in this high-risk group, establish its correlation with HVPG, and pioneer an integrated diagnosis-treatment protocol to reduce hospital stays and costs. The study runs from July 2025 to June 2027 at Zhejiang University School of Medicine.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 42 (estimated)
- First submitted
- 24 Jun 2025
- Start date
- 1 Jul 2025
- Primary completion date
- 30 Sept 2026
- Lead sponsor
- Zhejiang University
- Diseases
- High blood pressure
- NCT number
- NCT07062289
What you commit to
- Study type: Interventional
- Planned participants: 42
- From 1 Jul 2025 to the primary completion date, 30 Sept 2026
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Patients with renal insufficiency
- Patients with active infection
- Patients with immunodeficiency diseases (such as systemic lupus erythematosus)
- Patients with mental illness
- Patients with malignant tumors
Other
- Patients with ascites
- Patients with hepatic encephalopathy
- Critically ill patients
- Pregnant patients
- Patients who refused to undergo HVPG and EUS-PPG measurements
Who the study is looking for
- Age ≥ 18 years old
- History of liver cirrhosis
- INR \< 1.5
- Platelet count \> 50 × 10⁹/L
- Patients agreed to HVPG and EUS-PPG measurements
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.