NCT07063550Active, not recruiting
Microplastics in Paraneoplastic and Intratumoral for Colorectal Cancer
Identification of Paraneoplastic and Intratumoral Microplastics in Colorectal Cancer and Their Association Analysis With Macrogenomics and Metabolomics
Source: ClinicalTrials.gov · Last updated 14 Jul 2025
Brief summary (registry, in English)
The objective of this study is to identify and characterize microplastics present in peritumoral and intratumoral tissues of colorectal cancer patients, and to investigate their associations with gut microbiome composition and metabolic profiles. By integrating microplastic analysis with metagenomic and metabolomic data, we aim to explore the potential impact of environmental microplastic exposure on tumor microenvironment alterations, microbial dysbiosis, and metabolic reprogramming in colorectal cancer.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 100 (estimated)
- First submitted
- 3 Jul 2025
- Start date
- 1 Dec 2024
- Primary completion date
- 1 Oct 2026
- Lead sponsor
- Dong Peng
- Diseases
- Colorectal cancer
- NCT number
- NCT07063550
What you commit to
- Study type: Observational
- Planned participants: 100
- From 1 Dec 2024 to the primary completion date, 1 Oct 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of antibiotics, probiotics, or prebiotics within 4 weeks prior to sample collection.
Other illness
- Patients with a history of other malignancies within the past 5 years.
- Emergency surgery due to obstruction, perforation, or bleeding.
- Presence of chronic inflammatory bowel disease (e.g., Crohn's disease or ulcerative colitis).
Other
- Inadequate sample quality or volume for microplastic, metagenomic, or metabolomic analysis.
- Pregnant or breastfeeding women.
- Refusal or inability to provide informed consent.
Who the study is looking for
- Adult patients (≥18 years old) with histologically confirmed colorectal adenocarcinoma.
- Undergoing elective radical colorectal cancer resection at the study hospital.
- No prior chemotherapy, radiotherapy, or targeted therapy before surgery.
- Availability of both tumor tissue and adjacent normal (peritumoral) tissue samples during surgery.
- Willingness to provide stool and/or blood samples for metagenomic and metabolomic analysis.
- Ability to understand the study procedures and provide written informed consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The First Affiliated Hospital of Chongqing Medical University Coordinator of this site? Confirm its status | Chongqing | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.