NCT07066475Recruiting
A Registry-Based Cohort Study on the Clinical Outcomes of Spinal Cord Glioma Resection Via the Dorsolateral Sulcus Approach
Source: ClinicalTrials.gov · Last updated 23 Jul 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Spinal cord gliomas are the most common type of primary intramedullary malignant tumors, with a low incidence and a peak onset age of approximately 35 years. They are slightly more prevalent in males than females. Clinical manifestations vary depending on tumor characteristics and location, typically presenting with axial pain and displaying a tendency for unilateral, infiltrative growth. Prognosis is generally poor, and effective treatment options are limited aside from surgical resection. Common surgical approaches for intramedullary tumor removal include the posterior median sulcus approach, the dorsolateral sulcus approach, and surface entry techniques. Preliminary clinical observations suggest that the dorsolateral sulcus approach may offer superior preservation of neurological function and quality of life. However, due to limited research evaluating the safety and efficacy of different surgical routes, the traditional posterior median sulcus approach remains widely used. This single-center, registry-based cohort study aims to compare the outcomes of spinal cord glioma resection via the dorsolateral sulcus approach versus the posterior median sulcus approach. Patients with laterally located tumors undergoing surgical treatment, classified according to the 2021 WHO criteria, will be included. Neurological function scores and quality-of-life assessments will be used to evaluate prognosis and survival, in order to determine the optimal surgical approach for spinal cord glioma resection.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 100 (estimated)
- First submitted
- 25 Jun 2025
- Start date
- 1 Jan 2022
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- Beijing Tiantan Hospital
- Diseases
- Childhood cancers
- NCT number
- NCT07066475
What you commit to
- Study type: Observational
- Planned participants: 100
- From 1 Jan 2022 to the primary completion date, 31 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Receipt of radiotherapy, chemotherapy, or anti-tumor biological therapy within 1 month prior to enrollment
- Receipt of immunotherapy within 3 months prior to enrollment
- Participation in other clinical trials within 3 months prior to enrollment
Other illness
- History of severe allergic reactions or known allergy-prone constitution
- Presence of other severe medical conditions or uncontrolled infections
- History of drug abuse, substance misuse, chronic alcoholism, or HIV infection
- Uncontrolled epileptic seizures or psychiatric disorders resulting in loss of self-control
Age
- Age under 3 years or over 75 years
Other
- Pregnant or breastfeeding women, or individuals of childbearing potential not using adequate contraception
Who the study is looking for
- Age between 3 and 75 years
- Undergoing surgical resection of spinal cord tumor
- Histopathological diagnosis of spinal cord glioma based on routine pathological examination
- Availability of complete clinical data and willingness to participate in follow-up
- Informed consent obtained from the patient and/or legal guardians or immediate family members
Age in the registry: 3 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University Coordinator of this site? Confirm its status | Beijing | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.