NCT07071506Recruiting
New Methods for Evaluating Preventive Migraine Treatment
Source: ClinicalTrials.gov · Last updated 19 May 2026
Brief summary (registry, in English)
The study aims to test interactions between drug and placebo-responses in acute migraine treatment and to assess variation in adverse events according to treatment information provided. Using a clinical within-subjects, balanced placebo design, patients with chronic migraine will receive four treatment conditions in a randomized order.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 28 May 2025
- Start date
- 19 Jun 2025
- Primary completion date
- 30 Sept 2028
- Lead sponsor
- University of Aarhus
- Diseases
- Migraine
- NCT number
- NCT07071506
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 19 Jun 2025 to the primary completion date, 30 Sept 2028
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of onabotulinumtoxinA as preventive migraine treatment during the 4 months before inclusion
- Use of opioid or barbiturate medications in the last four weeks before inclusion
Other illness
- Secondary headache disorders including medication overuse headache
- Severe psychiatric, vascular disease, or known liver disease
Lab values
- Use of other preventive migraine treatment except CGRP antagonists (However, participants are allowed to be on two stable preventive medication (antidepressant, calcium channel blockers, beta blockers or antiepileptic)- 2 months prior to inclusion until end of study), devices for migraine prevention such as transcranial magnetic stimulation and use of nerve blocks 3 months prior to inclusion
Other
- Alcohol abuse or substance abuse
- Current or planned pregnancy and lactation
Who the study is looking for
- Adults (18-65 years)
- ≥ 1-year history of migraine with or without aura according to the International Classification of Headache Disorders (ICHD-3) diagnostic criteria
- Known chronic migraine (headache occurring ≥ 15 days per month for \> 3 months, which on at least 8 days per month has the features of migraine headache) diagnosed before age 65
- Eligibility for preventive migraine treatment
- Ability to speak and read Danish
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Department of Psychology and Behavioral sciences, Aarhus BSS, Aarhus University Coordinator of this site? Confirm its status | Aarhus C | Denmark | Recruiting |
| Department of Neurology, Aarhus University Hospital Coordinator of this site? Confirm its status | Aarhus N | Denmark | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.