NCT07073924Not yet recruiting
Prescribe to Prevent HIV: A Hybrid Trial Helping Addiction Clinics Prevent HIV & Infections Through Safer Drug Use Support
Prescribe to Prevent HIV (P2PH): Enhancing Clinic-based Prescribing of Harm Reduction: A Clinical Trial to Prevent HIV and Severe Injection-related Infections Among PWID
Source: ClinicalTrials.gov · Last updated 9 Jun 2026
Brief summary (registry, in English)
In the U.S., an estimated 3.6 million people who inject drugs (PWID) face a growing yet preventable health crisis, with rising cases of serious injection-related infections (SIRI), including HIV, due to limited access to two high-priority interventions: sterile injection equipment and daily oral HIV pre-exposure prophylaxis (PrEP). Outpatient clinics represent an opportune venue to implement these interventions. Yet most clinical providers in these settings do not currently provide them, contributing to a wide gap between evidence and routine practice. The Prescribe to Prevent HIV (P2PH) trial is a participatory study designed to co-develop and pilot test a set of implementation strategies to support outpatients clinics in offering sterile injection equipment and PrEP with the goal of reducing the risk of HIV and SIRI among PWID. This study is supported by the HEAL Initiative (https://heal.nih.gov/).
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 536 (estimated)
- First submitted
- 16 Jul 2025
- Start date
- 1 Aug 2026
- Primary completion date
- Dec 2027
- Lead sponsor
- University of Pittsburgh
- Diseases
- HIV
- NCT number
- NCT07073924
What you commit to
- Study type: Interventional
- Planned participants: 536
- From 1 Aug 2026 to the primary completion date, Dec 2027
- 4 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Residence or discharge to a treatment facility that bans the possession of drug checking supplies
Other illness
- If history of injection drug use \>1 year
- Acute, severe psychiatric condition in need of immediate treatment.
- Clinical Partners:
- Pre-implementation interviews (N=12), pre-implementation focus groups (N = 24), post-implementation surveys (N = 80), and post-implementation interviews (N=10)
Age
- Ages \<18
Other
- Non-English speaking
- Pending or legal action that could prohibit or interfere with participation (Ie. incarceration)
- Individuals not affiliated with the 4 COEs.
- Staff outside the specified roles (i.e., not prescribing clinicians, administrators, medical assistants, or nurses).
- Students, trainees, or individuals not credentialed in the eligible roles.
- Those on extended leave or not actively working during the study period.
Who the study is looking for
- -Adult patients with history of active injection drug use in the past 1 year from the 4 COEs
- -Prescribing clinicians (e.g., physicians, advanced practice providers such as nurse practitioners and physician assistants), administrators, medical assistants, and nurses from the 4 COEs
Criteria the registry did not label
- Patients:
- Pre-implementation interviews (N=12), pre-implementation focus groups (N=8), and post-implementation interviews (N=10)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Center for Psychiatric And Chemical Dependency Services Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
| UPMC-Magee Womens Hospital Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
| Internal Medicine Recovery Engagement Program Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
| Latterman Family Health Center Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.