NCT07081152Recruiting
Iron Absorption and Losses in Young South African Women Living Without and With Overweight and Obesity
Long-term Iron Absorption and Losses in Young South African Women Living Without and With Overweight and Obesity
Source: ClinicalTrials.gov · Last updated 23 Mar 2026
Brief summary (registry, in English)
Young women living with obesity (OB) have a greater risk of developing iron deficiency. Plus, the risk of anemia and/or ID in young women living with overweight (OW) and obesity (OB) is further increased by inadequate dietary intake and/or poor bioavailability of iron, as well as gastrointestinal and menstrual iron losses. It is not certain whether women living with OW/OB can meet their iron requirements from their day-to-day diet. The aim of this study is to compare iron absorption and losses over a long period between women living with and without OW and OB. Secondary outcomes include iron and inflammation status, as well as dietary iron intake.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 70 (estimated)
- First submitted
- 3 Jul 2025
- Start date
- 24 Jul 2025
- Primary completion date
- 30 Jun 2027
- Lead sponsor
- Linda Malan
- Diseases
- Obesity
- NCT number
- NCT07081152
What you commit to
- Study type: Interventional
- Planned participants: 70
- From 24 Jul 2025 to the primary completion date, 30 Jun 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current use of chronic anti-inflammatory medication, like corticosteroids or non-steroidal anti-inflammatory medication
- Regular use of antacids, proton pump inhibitors or H2 blockers
- Additional inclusion criteria applicable to phase 2 of the study
Other illness
- Treated or self-reported chronic or malabsorptive disorder
Lab values
- Hemoglobin \< 11 g/dl
Other
- Pregnancy or planning to become pregnant in the next 2 years
- Lactation
- Fear of needles or experiencing vaso-vagal episodes when exposed to blood
- Difficulty drawing blood due to poor quality veins
- Blood donation in the past 4 months or plans to donate blood during the study
- On a weight-loss diet or program or planning to start the same during the study
- Smoking
- Unwillingness to stop taking iron and /or vitamin C-containing supplements during phase 1 of the study
- Labelled with stable iron isotope (tracer) for a minimum of one year
- Willingness not to start or stop contraceptive use during the 6 months
- BMI ≥ 18.5 to 24.9 kg/m2 for participants living without OW/OB and BMI ≥ 28 kg/m2 for participants living with OW/OB
- Additional exclusion criteria applicable to phase 2 of the study
- \- Blood transfusion, intravenous iron infusion, blood donation or significant blood loss during the equilibration period
Who the study is looking for
- Of African descent
- BMI of 18.5 to 24.9 kg/m2 for participants living without OW/OB and BMI ≥ 28 kg/m2 for participants living with OW/OB
- Having low to moderate inflammation-adjusted iron stores (ferritin ≤50 µg/L)
- Absence of low-grade inflammation (CRP\<2 mg/l) for participants living without OW/OB and presence of low-grade inflammation CRP 2-20 mg/l) for participants living with OW/OB
- Planning to reside in the study area for at least 2 years
Age in the registry: 18 years to 35 years · Sex: Female · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Esté Vorster Research Facility Coordinator of this site? Confirm its status | Potchefstroom | South Africa | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.