NCT07082816CompletedPhase 3
Reformulated PG324 Ophthalmic Solution for Intraocular Pressure Reduction
A Phase III, Prospective, Double-Masked, Randomized, Multi-Center, Active-Controlled, Parallel Group Comparison Study Assessing the Ocular Hypotensive Efficacy of Reformulated PG324 Ophthalmic Solution in Subjects With Elevated Intraocular Pressure
Source: ClinicalTrials.gov · Last updated 21 Apr 2026
Brief summary (registry, in English)
This study is designed to see how safe and effective a new eye drop, called Reformulated PG324, is for lowering eye pressure in people with open-angle glaucoma (OAG) or ocular hypertension (OHT).
- Status (registry)
- Completed
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 489 (actual)
- First submitted
- 17 Jul 2025
- Start date
- 2 Sept 2025
- Primary completion date
- 6 Apr 2026
- Lead sponsor
- Alcon Research
- Diseases
- Glaucoma, High blood pressure
- NCT number
- NCT07082816
What you commit to
- Study type: Interventional · Phase 3
- Participants enrolled: 489
- From 2 Sept 2025 to the primary completion date, 6 Apr 2026
- 30 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current use of more than 2 ocular hypotensive medications within 30 days;
- Use of topical ocular medication of any kind within 5 days of Screening or throughout the study with the exception of ocular hypotensive medications (must be washed out).
Other
- Intraocular pressure greater than 36 millimeters mercury (mmHg) at Screening;
Who the study is looking for
- Diagnosis of open-angle glaucoma or ocular hypertension in both eyes;
- Unmedicated intraocular pressure measurements in the study eye as specified in the protocol;
- Corrected distance visual acuity equal to or better than 20/100 in the study eye.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (30)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Midwest Eye Center Coordinator of this site? Confirm its status | Cincinnati | United States | Unknown status |
| University Hospitals Cleveland Medical Center* Coordinator of this site? Confirm its status | Cleveland | United States | Unknown status |
| Coldwater Vision Research Coordinator of this site? Confirm its status | Coldwater | United States | Unknown status |
| Scott & Christie and Associates, PC Coordinator of this site? Confirm its status | Cranberry Township | United States | Unknown status |
| Central Florida Eye Specialists Coordinator of this site? Confirm its status | DeLand | United States | Unknown status |
| Glaucoma Specialists of South Florida Coordinator of this site? Confirm its status | Delray Beach | United States | Unknown status |
| Trinity Research Group Coordinator of this site? Confirm its status | Dothan | United States | Unknown status |
| Albemarle Eye Center Coordinator of this site? Confirm its status | Elizabeth City | United States | Unknown status |
| North Georgia Eye Associates Coordinator of this site? Confirm its status | Gainesville | United States | Unknown status |
| Orange County Ophthalmology Medical Group Coordinator of this site? Confirm its status | Garden Grove | United States | Unknown status |
| Oculus Research, Inc. Coordinator of this site? Confirm its status | Garner | United States | Unknown status |
| Las Vegas Eye Institute Coordinator of this site? Confirm its status | Henderson | United States | Unknown status |
| United medical research institute Coordinator of this site? Confirm its status | Inglewood | United States | Unknown status |
| East Coast Institute for Research, LLC Coordinator of this site? Confirm its status | Jacksonville | United States | Unknown status |
| Central Florida Eye Associates Coordinator of this site? Confirm its status | Lakeland | United States | Unknown status |
| The Eye Institute of West Florida Coordinator of this site? Confirm its status | Largo | United States | Unknown status |
| Lee Shettle Eye Coordinator of this site? Confirm its status | Largo | United States | Unknown status |
| Piedmont Eye Center Coordinator of this site? Confirm its status | Lynchburg | United States | Unknown status |
| Total Eye Care, PA Coordinator of this site? Confirm its status | Memphis | United States | Unknown status |
| Southern College of Optometry Coordinator of this site? Confirm its status | Memphis | United States | Unknown status |
| Eye Research Foundation Coordinator of this site? Confirm its status | Newport Beach | United States | Unknown status |
| North Bay Eye Associates Coordinator of this site? Confirm its status | Petaluma | United States | Unknown status |
| Eye Doctors of Arizona Coordinator of this site? Confirm its status | Phoenix | United States | Unknown status |
| Kannarr Eye Care LLC Coordinator of this site? Confirm its status | Pittsburg | United States | Unknown status |
| Rochester Ophthalmological Group Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| Coastal Research Associates Coordinator of this site? Confirm its status | Roswell | United States | Unknown status |
| Sacramento Eye Consultants Coordinator of this site? Confirm its status | Sacramento | United States | Unknown status |
| The Eye Institute of Utah Coordinator of this site? Confirm its status | Salt Lake City | United States | Unknown status |
| CORE, Inc. Coordinator of this site? Confirm its status | Shelby | United States | Unknown status |
| NorthEast Eye Research Associates, LLC Coordinator of this site? Confirm its status | Westborough | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.