NCT07085325Recruiting
CSIMEMPHIS: Long-term Follow-up of Medulloblastoma Survivors That Received Craniospinal Irradiation
Source: ClinicalTrials.gov · Last updated 6 Jul 2026
Brief summary (registry, in English)
The study is being done to learn more about the long-term health and well-being of participants treated for medulloblastoma. The study is to decide which evaluations focusing on therapy-related lasting effects (or toxicities) should be considered. Medulloblastoma outcomes have improved with contemporary therapies including modern neurosurgical techniques and risk-adapted radiotherapy and chemotherapy regimens. However, survivors remain at risk for long-term health problems such as neurocognitive deficits, hearing loss, impaired cardiorespiratory fitness and physical performance, cardiac and neuroendocrine dysfunction, musculoskeletal conditions, and infertility.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 184 (estimated)
- First submitted
- 2 Jul 2025
- Start date
- 20 Apr 2026
- Primary completion date
- Oct 2030
- Lead sponsor
- St. Jude Children's Research Hospital
- Diseases
- Childhood cancers
- NCT number
- NCT07085325
What you commit to
- Study type: Observational
- Planned participants: 184
- From 20 Apr 2026 to the primary completion date, Oct 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Participants who had relapsed or refractory disease during or following completion of treatment for medulloblastoma
Other
- Participants or their legal guardian/representative are unwilling or unable to provide written informed consent.
Who the study is looking for
- Diagnosis of any subtype of medulloblastoma between the ages of 3 to 22 years or between the ages of 22 to 44 years with the sonic hedgehog (SHH) subtype of medulloblastoma
- Radiotherapy on or according to the SJMB12 protocol
- Received radiotherapy at St. Jude Children's Research Hospital
- 5 or more years since the initiation of radiation therapy and who did not have evidence of disease progression
- Provision of informed consent by participant/guardian or legal representative; Assent by minor participant
- Participants may choose to complete all or a subset of the proposed assessments; refusal to participate in some aspects of the study will not preclude participant inclusion
- Participants must also complete enrollment on SJLIFE
Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| St. Jude Children's Research Hospital Coordinator of this site? Confirm its status | Memphis | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.