NCT07085494Enrolling by invitation
Neurofeedback and Cognitive Training for PBTS
A Double-Blind, Sham-Controlled Trial Investigating Individualized Alpha Neurofeedback Plus Cognitive Training in Paediatric Brain Tumour Survivors
Source: ClinicalTrials.gov · Last updated 27 Jan 2026
Brief summary (registry, in English)
Brief Summary of the Study: This study is a prospective, randomized, sham-controlled, triple-blind trial investigating whether combining individualized alpha neurofeedback (NF) with cognitive training (Cogmed) can improve cognitive functioning in pediatric brain tumor survivors (PBTS), a group at risk for persistent cognitive difficulties after cancer treatment. Participants (ages 6-18) who have completed primary cancer therapy and report cognitive problems are randomly assigned to either (1) individualized alpha NF plus Cogmed or (2) sham NF plus Cogmed. Both interventions include eight one-hour sessions over four weeks, with neurofeedback (real or sham) followed by Cogmed training. The primary outcome is cognitive performance measured by CNS Vital Signs at baseline, post-intervention, and 12-month follow-up. Secondary outcomes include attention, executive function, behavior, and quality of life (measured by SWAN, BRIEF, SDQ, and PedsQL). The study uses rigorous double-blinding and intention-to-treat analysis, with sample size planned at 40-60 participants. Results will determine if individualized alpha NF, when combined with cognitive training, yields greater cognitive and behavioral benefits than cognitive training alone in PBTS.
- Status (registry)
- Enrolling by invitation
- Study type
- Interventional
- Enrollment
- 50 (estimated)
- First submitted
- 17 Jul 2025
- Start date
- 1 Aug 2025
- Primary completion date
- 31 Aug 2027
- Lead sponsor
- The University of Hong Kong
- Diseases
- Childhood cancers
- NCT number
- NCT07085494
What you commit to
- Study type: Interventional
- Planned participants: 50
- From 1 Aug 2025 to the primary completion date, 31 Aug 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Medication regimens that significantly interfere with EEG signals and cannot be safely adjusted
Other illness
- \- Severe neurological or psychiatric conditions (for example, uncontrolled seizures) that preclude EEG monitoring or completing computer-based training
Other
- Severe sensory or motor deficits that would make training infeasible
- Inability or unwillingness to follow study protocol
Who the study is looking for
- \- Paediatric brain tumour survivors aged 6 to 18 years
- Completion of primary cancer treatment (for example, surgery, chemotherapy, or radiotherapy) at least six months prior
- Documented or reported cognitive difficulties in attention or executive functioning
- Ability and willingness to attend scheduled sessions over four weeks
Age in the registry: 6 years to 18 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hong Kong Children's Hospital Coordinator of this site? Confirm its status | Hong Kong | Hong Kong SAR China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.