NCT07086833Recruiting
The Food Environment, Microbial Cysteine Metabolism, and Cancer Disparities
Source: ClinicalTrials.gov · Last updated 14 May 2026
Brief summary (registry, in English)
The goal of this clinical trial is to learn if changing cysteine levels in the diet can influence how the body processes cysteine in Black and White individuals aged 45-75 with a history of non-cancerous polyps. The main questions it aims to answer are: * At the beginning of the study, do Black participants have higher levels of cortisol (a stress hormone) and compounds made from cysteine in their blood when compared to White participants? * Does eating less cysteine lower the body's natural cysteine activity and lead to less gut bacteria that break down cysteine? * Does eating less cysteine lead to less inflammation in the gut and lower levels of markers of inflammation in the blood? Research will compare a high cysteine diet and a low cysteine diet, and each participant will eat both diets. Participants will be in the study for 11 weeks and 2 days. Over the course of the study, participants will: * Eat a high cysteine diet for 3 weeks, and a low cysteine diet for 3 weeks * Eat a moderate cysteine diet for 1 week before each study diet * Complete surveys * Provide blood, stool, and saliva samples * Maintain food logs
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 17 Jul 2025
- Start date
- 18 Aug 2025
- Primary completion date
- 1 Dec 2027
- Lead sponsor
- Purdue University
- Diseases
- Colorectal cancer
- NCT number
- NCT07086833
What you commit to
- Study type: Interventional
- Planned participants: 40
- From 18 Aug 2025 to the primary completion date, 1 Dec 2027
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of illicit drugs, combustible tobacco, or dietary supplements
- Weight gain or loss \> 4 kg 3 months prior to study
Other illness
- A history of organ transplantation
- A history of cancer treatment within the past 12 months
- Significant food allergies, food preferences or therapeutic or vegetarian diets
- Significant medical conditions
- History of eating disorders
Age
- Individuals under the age of 18
Other
- Antibiotic use within the last 6 months
- Abnormal gastrointestinal transit
- Pre- or probiotics within the last two months
- CRC or a genetic predisposition to CRC
- A baseline body weight \> 450 lbs
- Menstrual cycle within the last 6 months
- Antibiotics in the last 2 months
- Cannot keep a food record for 7 consecutive days during screening after detailed instruction
- Alcoholism
Who the study is looking for
- Aged 45-75
- Up to date with CRC screening colonoscopy with a high risk of CRC, defined as a history of 3 or more adenomatous polyps (APs) or an AP \>1 cm in the past 5 years
- Identify as Black or Non-Hispanic White
- If female, no menstrual period for at least six months
- Willingness to donate oral wash and stool samples
- Willingness to complete 24-hour dietary recalls
Age in the registry: 45 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Hospital Clinical Research Center Coordinator of this site? Confirm its status | Indianapolis | United States | Not yet recruiting |
| Purdue Clinical Research Center Coordinator of this site? Confirm its status | West Lafayette | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.