NCT07087951Recruiting
Efficacy of Gamma Auditory Stimulation for Cognitive Decline in Older Adults (Study 1)
Development and Validation of an Innovative Gamma Auditory Stimulation System for Older Adults With Cognitive Decline: A Randomized, Double-blind, Placebo-controlled Study (Study 1)
Source: ClinicalTrials.gov · Last updated 17 Aug 2026
Brief summary (registry, in English)
Animal studies have shown that 40 Hz auditory stimulation alone can improve spatial memory and reduce Aβ deposition. However, human studies using 40 Hz auditory stimulation alone remain limited. Therefore, this study will use a randomized, double-blind, placebo-controlled design to investigate the effects of 40 Hz auditory stimulation on cognitive function, EEG activity, sleep quality, and quality of life in older adults with mild cognitive impairment (MCI) or mild dementia.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 70 (estimated)
- First submitted
- 7 Jul 2025
- Start date
- 14 Nov 2025
- Primary completion date
- 1 Sept 2028
- Lead sponsor
- Chang Gung Memorial Hospital
- Diseases
- Alzheimer disease
- NCT number
- NCT07087951
What you commit to
- Study type: Interventional
- Planned participants: 70
- From 14 Nov 2025 to the primary completion date, 1 Sept 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Drug or alcohol addictions.
Other illness
- Diagnosis of other psychiatric or neurological disorders
- Serious heart, liver or kidney disorders, and visual, auditory or motor impairments interfering with neuropsychological tests.
- History of clinical stroke, major depressive disorder or dysthymic disorder according to the DSM-5.
Who the study is looking for
- Age over 60 years old.
- MMSE≤ 24
- CDR scores of 0.5 and 1
- Voluntary to sign the Informed Consent Form.
Age in the registry: 60 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Chang Gung University Coordinator of this site? Confirm its status | Taoyuan | Taiwan | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.