NCT07088445Not yet recruiting
Therapeutic Prospects of Faricimab Injection for Patients Affected by Neovascular Age-Related Macular Degeneration
Source: ClinicalTrials.gov · Last updated 28 Jul 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Neovascular Age-Related Macular Degeneration (nAMD) is one of the main causes of irreversible vision loss in the elderly, characterized by neovascularization and vascular leakage in the macular area, ultimately leading to damage to retinal structure and visual impairment. At present, anti vascular endothelial growth factor (VEGF) therapy is the main approach for treating nAMD, including VEGF inhibitors such as Aflibercept and Conbercept. However, some patients show decreased treatment tolerance or efficacy after long-term use of these drugs . Faricimab, a bispecific antibody that targets both VEGF and angiopoietin-2 (Ang-2), is expected to provide a new treatment option for patients resistant to existing VEGF therapies due to its unique dual mechanism of action The aim of this study is to explore the treatment response rate and prognosis of farnesyl monoclonal antibody in patients with refractory nAMD, including visual improvement and imaging changes, in order to provide more scientific treatment decision-making basis for clinical practice. At the same time, to determine its efficacy and safety in actual clinical treatment, in order to provide more flexible and personalized treatment options for nAMD patients, reduce their treatment burden, improve treatment compliance and quality of life.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 35 (estimated)
- First submitted
- 26 Jun 2025
- Start date
- Sept 2025
- Primary completion date
- Jun 2026
- Lead sponsor
- Hui Peng
- Diseases
- Macular degeneration
- NCT number
- NCT07088445
What you commit to
- Study type: Observational
- Planned participants: 35
- From Sept 2025 to the primary completion date, Jun 2026
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Having undergone eye surgery (such as retinal laser treatment or vitrectomy) and less than 3 months after surgery.
Other illness
- Accompanied by other eye diseases that may affect the structure or function of the macula (such as diabetes retinopathy, uveitis, etc.). There are obvious scars or fibrosis on the vitreous or retina.
- There is uncontrolled hypertension, diabetes or other systemic diseases that may affect the treatment effect.
- Allergic to farnesyl monoclonal antibody or its components.
Other
- Patients who are unable to complete follow-up or have poor compliance.
- Researchers determine other factors that may affect the safety or data integrity of the experiment.
Who the study is looking for
- Diagnosis of wet age-related macular degeneration (nAMD) in individuals aged 50 years to 80 years.
- Refractory nAMD: ≥ 6 injections of anti VEGF drugs within 12 months or ≥ 4 injections within 6 months, CFT ≥300 μm， In addition, there is retinal fluid.
- BCVA is 24 to 73 letters (equivalent to Snellen vision of about 20/40 to 20/320) in the early treatment of diabetes retinopathy study (ETDRS) scoring scale.
- The subjects can understand the purpose of the study and voluntarily sign a written informed consent.
Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.