NCT07091838Completed
Lung Diffusing Capacities Normality Thresholds in Pulmonary Fibrosis and Emphysema
Lung Diffusing Capacity Thresholds for the Assessment of Pulmonary Fibrosis and Emphysema: a Structure-to-function Study
Source: ClinicalTrials.gov · Last updated 29 Jul 2025
Brief summary (registry, in English)
The investigators tested the usefulness of lung diffusing capacities for carbon monoxide (DLco) and nitric oxide (DLNO) normality thresholds of 5th and 2.5th percentiles for the assessment of intersitial pulmonary fibrosis (IPF) and pulmonary emphysema (PE). Computed tomography (CT) of the chest was taken as a gold standard for the presence of lung parenchymal abnormalities typical of these conditions. The investigators retrospectively utilized the DLco and DLNO data obtained by a single device in sixty-six subjects with IPF included in two previous studies and in fifty-four new subjects with PE, both documented by quantitative CT of the chest.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 120 (actual)
- First submitted
- 16 Jul 2025
- Start date
- 13 May 2025
- Primary completion date
- 30 Jun 2025
- Lead sponsor
- IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
- Diseases
- COPD
- NCT number
- NCT07091838
What you commit to
- Study type: Observational
- Participants enrolled: 120
- From 13 May 2025 to the primary completion date, 30 Jun 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- All subjects with history of any comorbidities potentially affecting lung diffusing capacity, i.e., congestive heart failure, liver or kidney diseases, and morbid obesity
Who the study is looking for
- Asymptomatic healthy controls with lung function parameters above the LLN5, i.e., -1.645 z-score
- Subjects of white European ancestry with CT-determined IPF and/or PE
Age in the registry: 18 years to 85 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| IRCCS Ospedale Policlinico San Martino Coordinator of this site? Confirm its status | Genova | Italy | Unknown status |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.