NCT07094906Not yet recruiting
Handgrip Exercise Training and CKD
Neural and Vascular Modulation With Isometric Handgrip Training in Chronic Kidney Disease
Source: ClinicalTrials.gov · Last updated 10 Jun 2026
Brief summary (registry, in English)
The purpose of this study is to find out if regular handgrip exercise performed at home can improve blood pressure at rest and during exercise in patients with chronic kidney disease (CKD). This study is also intended to understand what causes an increase in blood pressure at rest and during exercise (i.e., increased adrenaline levels, or decreased ability of blood vessels to dilate). Patients with CKD will be recruited from primary care, Nephrology and other subspecialty Clinics throughout the Emory Healthcare System. Participants will attend 4 visits of 2-3 hours and 3 visits of 1-2 hours. The home exercise training will last for 8 weeks.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 50 (estimated)
- First submitted
- 25 Jul 2025
- Start date
- Sept 2026
- Primary completion date
- Dec 2027
- Lead sponsor
- Emory University
- Diseases
- Chronic kidney disease
- NCT number
- NCT07094906
What you commit to
- Study type: Interventional
- Planned participants: 50
- From Sept 2026 to the primary completion date, Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Ongoing drug or alcohol abuse
- Current treatment with MAO inhibitors
Other illness
- Any serious systemic disease that might influence survival
- Uncontrolled hypertension with BP greater than 170/100 mm Hg
Lab values
- Severe CKD (eGFR\<15 cc/minute)
- Metabolic alkalosis (serum bicarbonate \> 28 meq/L)
- Severe anemia with hgb level \<10 g/dL
- Clinical evidence of congestive heart failure or ejection fraction below 35%, symptomatic heart disease determined by prior electrocardiogram, stress test, and/or history, treatment with central alpha agonists (clonidine)
Other
- Diabetic neuropathy
- Low blood pressure with BP less than 100/50
- Pregnancy or plans to become pregnant
- Inability to perform handgrip exercise
Who the study is looking for
- Patients with CKD (Stages IIIa and IV),
- Ages 45-85 years who do not regularly exercise (defined as exercising less than 20 minutes twice per week), willing and able to cooperate with the protocol.
- CKD Stages III and IV will be defined as reduction in estimated glomerular filtration rate (eGFR) to 15-59 cc/minute as calculated by the modified CKD-EPI equations.
- Patients with CKD must have stable renal function (no greater than a 20% reduction in eGFR over the prior 3 months).
Age in the registry: 45 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Emory University Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.