NCT07095816CompletedPhase 1
Acetaminophen Before Surgery Lowers Postop Pain in Pediatric Solid Tumor Patients (ERAS)
Administering Acetaminophen Orally Before Surgery Reduces Postoperative Pain in Children With Solid Tumors Under the Mode of ERAS
Source: ClinicalTrials.gov · Last updated 31 Jul 2025
Brief summary (registry, in English)
Pain is the predominant subjective symptom experienced during the perioperative period in pediatric patients with solid tumors. Intense pain may impede early postoperative activities and delay the recovery process. Preemptive analgesia，as a component of multimodal analgesia strategies，aims to mitigate pain by administering analgesic interventions prior to the application of a noxious stimulus. This approach seeks to diminish both peripheral and central sensitization to pain，thereby alleviating postoperative pain. Currently，while preoperative acetaminophen is widely used in adult surgeries，research is limited for its use in pediatrics. This study aims to evaluate the impact of preemptive acetaminophen on reducing postoperative pain in children with solid tumors under the mode of ERAS.
- Status (registry)
- Completed
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 182 (actual)
- First submitted
- 13 Jul 2025
- Start date
- 15 May 2023
- Primary completion date
- 27 Feb 2025
- Lead sponsor
- Nanjing Children's Hospital
- Diseases
- Childhood cancers
- NCT number
- NCT07095816
What you commit to
- Study type: Interventional · Phase 1
- Participants enrolled: 182
- From 15 May 2023 to the primary completion date, 27 Feb 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Lab values
- Lack of Informed Consent: Parental/guardian informed consent was not obtained. ②Allergy/Intolerance: Known hypersensitivity or contraindication to acetaminophen (paracetamol).
- Hepatic Impairment:Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) levels \>3× the upper limit of normal (ULN).
- Renal Dysfunction:Serum urea or creatinine levels exceeding the ULN. ⑤Recent Analgesic Use: Administration of any analgesic medication within 12 hours preoperatively.
- PCA Exclusion: Patients not receiving postoperative intravenous patient-controlled analgesia (PCA).
Who the study is looking for
- Informed Consent: Written informed consent was obtained from the parents or legal guardians of all pediatric participants.
- Age Requirement: Patients aged \>1 month (infants and children) were eligible for enrollment.
- Diagnosis \& Treatment:
- Radiologically or pathologically confirmed solid tumors. Ⅱ.Scheduled to undergo tumor resection surgery in the Department of Pediatric Surgical Oncology, Children's Hospital Affiliated to Nanjing Medical University.
Age in the registry: 1 month to 15 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Children's Hospital of Nanjing Medical University Coordinator of this site? Confirm its status | Nanjing | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.