NCT07097220Completed
Effects of Different Anesthetic Techniques on Intraoperative and Postoperative Pain Levels and Cognitive Function in Patients Undergoing Hepatectomy for Liver Cancer
Source: ClinicalTrials.gov · Last updated 31 Jul 2025
Brief summary (registry, in English)
To evaluate the effects of general anesthesia (GA) versus combined general and epidural anesthesia (GEA) on postoperative pain, cognitive dysfunction (POCD), hospital stay, and recovery quality in liver cancer patients undergoing hepatectomy. A retrospective analysis of 80 liver cancer patients was conducted, categorized by analgesic adequacy, pain recovery, and POCD incidence: adequate vs. inadequate analgesia (n=50 vs. n=30), favorable vs. delayed pain recovery (n=36 vs. n=44), and POCD vs. non-POCD (n=42 vs. n=38). Based on these results, a prospective study (April 2024-April 2025) enrolled patients scheduled for elective hepatectomy, assigned to the GA group (n=59) or GEA group (n=47). Primary outcomes included intraoperative analgesic consumption, postoperative VAS pain scores, MoCA cognitive scores, hospital stay length, and adverse event rates.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 106 (actual)
- First submitted
- 30 Jun 2025
- Start date
- 16 May 2025
- Primary completion date
- 13 Jun 2025
- Lead sponsor
- Sir Run Run Shaw Hospital, Qingchun Campus, Zhejiang University School of Medicine,
- Diseases
- Liver and biliary tract cancer
- NCT number
- NCT07097220
What you commit to
- Study type: Interventional
- Participants enrolled: 106
- From 16 May 2025 to the primary completion date, 13 Jun 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Criteria the registry did not label
- Inclusion Criteria:
- Histologically or radiologically confirmed primary liver cancer (HCC or cholangiocarcinoma)
- Scheduled for elective open or laparoscopic radical hepatectomy
- Age 18-75 years
- ASA Physical Status I-III
- Child-Pugh class A or B liver function
- Normal preoperative MoCA score (≥26)
- Willing to participate and provide informed consent
- Exclusion Criteria:
- Severe cardiovascular, pulmonary or renal disease (ASA IV/V)
- Chronic pain disorders or preoperative opioid use (\>3 months)
- Known neurologic/psychiatric conditions (dementia, stroke, epilepsy)
- Concurrent major procedures (e.g., vascular resection)
- Intraoperative conversion to palliative surgery
- Massive intraoperative hemorrhage (\>2000 mL)
- Coagulopathy (INR \>1.5 or platelets \<50×10⁹/L)
- Spinal abnormalities precluding epidural catheterization
- Pregnancy or lactation
- Allergy to local anesthetics or study medications
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Sir Run Run Shaw Hospital Zhejiang University School of Medicine Coordinator of this site? Confirm its status | Hangzhou | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.