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NCT07097441CompletedPhase 1/2

To Observe Haemodynamic Parameters Including, Heart Rate, Blood Pressure, Respiratory Rate , and Oxygen Saturation, With or Without Giving Reversal Agent on Extubation, in Patients Receiving Single Shot of Atracurium , and to Observe Post Operative Residual Paralysis and Airway Reflexes in PACU.

Effect of the Use of Atracurium With or Without Reversal Agent on Haemodynamic Parameters During Extubation: a Randomized Controlled Trial

Source: ClinicalTrials.gov · Last updated 31 Jul 2025

Brief summary (registry, in English)

The goal of this clinical trial is to to observe the haemodynamic parameters including Heart Rate Blood pressure Respiratory rate and Oxygen Saturation with or without giving reversal agent on extubation in patients receiving atracurium on induction , it will also observe post operative residual paralysis respiratory depression and airway reflexes in the post anaesthesia care unit Researchers will compare neostigmine which is the reversal agent and the placebo drug by giving it at the end on surgery before extubation to observe haemodynamic parameters The main questions it aims to answer are Will participants have a stable haemodymaics if no reversal ( neostigmine ) is used during extubation Will it provide a safe extubation and no complications post operatively Participants will be given Either neostigmine or placebo drug at the end of surgery before extubation Will be obseved and monitored for two hours postoperatively in the post anaesthesia care unit Will be monitored for post operative complications like respiratory depression or residual paralysis .

Status (registry)
Completed
Phase (registry)
Phase 1/2
Study type
Interventional
Enrollment
100 (actual)
First submitted
17 Jul 2025
Start date
12 Mar 2025
Primary completion date
4 Jun 2025
Lead sponsor
Ziauddin University
NCT number
NCT07097441

What you commit to

  • Study type: Interventional · Phase 1/2
  • Participants enrolled: 100
  • From 12 Mar 2025 to the primary completion date, 4 Jun 2025
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Any previous reaction to atracurium

Other illness

  • Severe pulmonary cardiac kindney and liver disease

Other

  • American society of anaesthesiology class 3 and above
  • Active asthma

Who the study is looking for

  • American society of anaesthesiology class 1 and 2
  • Surgeries lasting for 60 mins
  • .Surgeries requiring general anaesthesia and tracheal intubation and single intubation dose of atracurium

Age in the registry: 16 years to 70 years · Sex: All · Accepts healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Ziauddin University
Coordinator of this site? Confirm its status
KarachiPakistanUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.