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NCT07099482Not yet recruiting

"Ultrasound-Enhanced Propolis Therapy for Healing Diabetic Foot Wounds"

Effectiveness of Propolis Phonophoresis on Wound Healing in Diabetic Ulcer: a Randomized Controlled Trial

Source: ClinicalTrials.gov · Last updated 4 Aug 2026

Brief summary (registry, in English)

This study aims to evaluate whether using ultrasound (phonophoresis) can help deliver propolis-a natural compound made by bees-more effectively into the skin to speed up wound healing in people with diabetic foot ulcers. Diabetic foot ulcers are a common and serious complication of diabetes and often take a long time to heal. Propolis has natural anti-inflammatory and antimicrobial properties that may promote healing, but it does not easily penetrate the skin. By using ultrasound to enhance absorption, this study tests whether combining propolis with phonophoresis is more effective than standard wound care alone. Participants will be randomly assigned to receive either the propolis ultrasound therapy or standard care. The study will measure wound size, healing time, pain, infection rates, and quality of life.

Status (registry)
Not yet recruiting
Study type
Interventional
Enrollment
80 (estimated)
First submitted
25 Jul 2025
Start date
30 Aug 2026
Primary completion date
25 Aug 2027
Lead sponsor
Sinai University
NCT number
NCT07099482

What you commit to

  • Study type: Interventional
  • Planned participants: 80
  • From 30 Aug 2026 to the primary completion date, 25 Aug 2027
  • No sites listed in no country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Use of systemic immunosuppressants or corticosteroids

Other illness

  • Severe infection or presence of osteomyelitis at the ulcer site
  • Known allergy or hypersensitivity to propolis

Other

  • Pregnant or breastfeeding women
  • Participation in another clinical trial within the past 30 days

Who the study is looking for

  • Adults aged 18 to 75 years
  • Diagnosed with type 1 or type 2 diabetes mellitus
  • Presence of a diabetic foot ulcer classified as Grade 1 or 2 (Wagner classification)
  • Ulcer size between 1 cm² and 5 cm²
  • Able and willing to provide informed consent

Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

This page is information, not medical advice. Discuss any trial with your doctor.