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NCT07100080RecruitingPhase 2/3

Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)

IZABRIGHT-Lung01: A Randomized, Open-label, Phase 2/3 Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-based Chemotherapy in Patients With EGFR-mutated Non-small Cell Lung Cancer and Disease Progression on EGFR Tyrosine Kinase Inhibitor Therapy

Source: ClinicalTrials.gov · Last updated 9 Oct 2026

Brief summary (registry, in English)

A Study of Izalontamab Brengitecan (BMS-986507) versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer after failure of EGFR TKI Therapy

Status (registry)
Recruiting
Phase (registry)
Phase 2/3
Study type
Interventional
Enrollment
500 (estimated)
First submitted
31 Jul 2025
Start date
Nov 2025
Primary completion date
Dec 2028
Lead sponsor
Bristol-Myers Squibb
Diseases
Lung cancer
NCT number
NCT07100080

What you commit to

  • Study type: Interventional · Phase 2/3
  • Planned participants: 500
  • From Nov 2025 to the primary completion date, Dec 2028
  • 187 sites in 25 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • Poorly controlled systemic medical conditions.

Other

  • Inadequate organ function and/or bone marrow reserve.
  • Leptomeningeal metastases or spinal cord compression.
  • Other protocol-defined inclusion/exclusion criteria apply.

Who the study is looking for

  • Non-squamous NSCLC, not amenable to treatment in curative intent.
  • Documented evidence of EGFR mutation (exon 19 deletion, L858R mutation).
  • Progressive disease on a 3rd-generation (such as osimertinib, furmonertinib, lazertinib,...) EGFR-TKI-based mono- or combination therapy regimen as the most recent line of therapy in an adjuvant, locally advanced, or metastatic treatment setting.
  • Eligible to receive a platinum-based doublet chemotherapy regimen (either cisplatin or carboplatin in combination with pemetrexed).

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (187)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Hospital Italiano de Buenos Aires
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ABBArgentinaRecruiting
Instituto Alexander Fleming
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Ciudad Autónoma de Buenos AiresArgentinaRecruiting
Hospital Privado Universitario de Córdoba
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CórdobaArgentinaRecruiting
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AuderghemBelgiumNot yet recruiting
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GhentBelgiumNot yet recruiting
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Sint-NiklaasBelgiumNot yet recruiting
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WilrijkBelgiumNot yet recruiting
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YvoirBelgiumNot yet recruiting
Arthur J.E. Child Comprehensive Cancer Centre
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CalgaryCanadaRecruiting
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ChicoutimiCanadaNot yet recruiting
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MontrealCanadaWithdrawn
Princess Margaret Cancer Centre
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TorontoCanadaRecruiting
Kantonsspital Baden
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BadenSwitzerlandRecruiting
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BellinzonaSwitzerlandNot yet recruiting
Cantonal Hospital St Gallen
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Sankt GallenSwitzerlandRecruiting
Orlandi Oncologia
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SantiagoChileRecruiting
Bradfordhill
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SantiagoChileRecruiting
FALP
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SantiagoChileRecruiting
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AnyangChinaNot yet recruiting
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BeijingChinaNot yet recruiting
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ChangchunChinaNot yet recruiting
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ChangshaChinaNot yet recruiting
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ChongqingChinaNot yet recruiting
Fujian Cancer Hospital
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FuzhouChinaRecruiting
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HangzhouChinaNot yet recruiting
Jiangmen Center Hospital
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JiangmenChinaRecruiting
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JinanChinaNot yet recruiting
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JingzhouChinaNot yet recruiting
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LinhaiChinaNot yet recruiting
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LuoyangChinaNot yet recruiting
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NanchangChinaNot yet recruiting
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NanningChinaNot yet recruiting
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ShanghaiChinaNot yet recruiting
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ShanghaiChinaNot yet recruiting
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ShenyangChinaNot yet recruiting
Shanxi Cancer hospital
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TaiyuanChinaRecruiting
Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology
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WuhanChinaRecruiting
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XuzhouChinaNot yet recruiting
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BogotáColombiaNot yet recruiting
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CaliColombiaNot yet recruiting
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MonteríaColombiaNot yet recruiting
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ValleduparColombiaNot yet recruiting
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BerlinGermanyNot yet recruiting
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ChemnitzGermanyNot yet recruiting
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CologneGermanyNot yet recruiting
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DonauwörthGermanyNot yet recruiting
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Esslingen am NeckarGermanyNot yet recruiting
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Esslingen am NeckarGermanyNot yet recruiting
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GautingGermanyNot yet recruiting
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HamburgGermanyNot yet recruiting
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HeidelbergGermanyNot yet recruiting
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KasselGermanyNot yet recruiting
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KielGermanyNot yet recruiting
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OldenburgGermanyNot yet recruiting
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StuttgartGermanyNot yet recruiting
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UlmGermanyNot yet recruiting
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BarcelonaSpainNot yet recruiting
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BarcelonaSpainNot yet recruiting
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MadridSpainNot yet recruiting
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MadridSpainNot yet recruiting
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MadridSpainNot yet recruiting
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MajadahondaSpainNot yet recruiting
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MálagaSpainNot yet recruiting
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SevilleSpainNot yet recruiting
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ValenciaSpainNot yet recruiting
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ZaragozaSpainNot yet recruiting
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BronFranceNot yet recruiting
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La TroncheFranceNot yet recruiting
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LilleFranceNot yet recruiting
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MarseilleFranceNot yet recruiting
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NantesFranceNot yet recruiting
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ParisFranceNot yet recruiting
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ParisFranceNot yet recruiting
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Saint-HerblainFranceNot yet recruiting
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StrasbourgFranceNot yet recruiting
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ToulouseFranceNot yet recruiting
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VillejuifFranceNot yet recruiting
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GlasgowUnited KingdomNot yet recruiting
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LondonUnited KingdomNot yet recruiting
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LondonUnited KingdomNot yet recruiting
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Sulton, SurreyUnited KingdomNot yet recruiting
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AthensGreeceNot yet recruiting
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ChaïdáriGreeceNot yet recruiting
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ThessalonikiGreeceNot yet recruiting
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ThessalonikiGreeceNot yet recruiting
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AhmedabadIndiaWithdrawn
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AhmedabadIndiaWithdrawn
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BengaluruIndiaNot yet recruiting
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GurugramIndiaWithdrawn
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HowrahIndiaWithdrawn
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MumbaiIndiaNot yet recruiting
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MumbaiIndiaNot yet recruiting
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NagpurIndiaNot yet recruiting
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New DelhiIndiaNot yet recruiting
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AvellinoItalyNot yet recruiting
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AvianoItalyNot yet recruiting
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CandioloItalyNot yet recruiting
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MilanItalyNot yet recruiting
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NaplesItalyNot yet recruiting
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OrbassanoItalyNot yet recruiting
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ParmaItalyNot yet recruiting
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RavennaItalyNot yet recruiting
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Chuo-kuJapanNot yet recruiting
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HamamatsuJapanNot yet recruiting
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HirakataJapanNot yet recruiting
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Ina-machiJapanWithdrawn
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KashiwaJapanNot yet recruiting
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Koto-kuJapanNot yet recruiting
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KurashikiJapanNot yet recruiting
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KurumeJapanNot yet recruiting
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Nagaizumi-cho,Sunto-gunJapanNot yet recruiting
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NagoyaJapanNot yet recruiting
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NishinomiyaJapanNot yet recruiting
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Ōsaka-sayamaJapanNot yet recruiting
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SapporoJapanNot yet recruiting
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SendaiJapanNot yet recruiting
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TōonJapanNot yet recruiting
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YokohamaJapanNot yet recruiting
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Cheongju-siSouth KoreaNot yet recruiting
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Goyang-siSouth KoreaNot yet recruiting
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SeongnamSouth KoreaNot yet recruiting
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SeoulSouth KoreaNot yet recruiting
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SeoulSouth KoreaNot yet recruiting
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SeoulSouth KoreaNot yet recruiting
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SeoulSouth KoreaNot yet recruiting
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SuwonSouth KoreaNot yet recruiting
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Chihuahua CityMexicoNot yet recruiting
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Mexico CityMexicoNot yet recruiting
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Mexico CityMexicoNot yet recruiting
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Oaxaca CityMexicoNot yet recruiting
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AmsterdamNetherlandsNot yet recruiting
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AmsterdamNetherlandsNot yet recruiting
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HarderwijkNetherlandsNot yet recruiting
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BergenNorwayNot yet recruiting
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DrammenNorwayNot yet recruiting
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OsloNorwayNot yet recruiting
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BydgoszczPolandNot yet recruiting
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LublinPolandNot yet recruiting
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PoznanPolandNot yet recruiting
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BucharestRomaniaWithdrawn
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BucharestRomaniaNot yet recruiting
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BucharestRomaniaNot yet recruiting
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Cluj-NapocaRomaniaNot yet recruiting
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CraiovaRomaniaNot yet recruiting
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FloreștiRomaniaWithdrawn
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IașiRomaniaNot yet recruiting
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IașiRomaniaNot yet recruiting
National Cancer Centre Singapore
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SingaporeSingaporeRecruiting
Tan Tock Seng Hospital
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SingaporeSingaporeRecruiting
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BangkokThailandNot yet recruiting
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BangkokThailandNot yet recruiting
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MuengThailandNot yet recruiting
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SongkhlaThailandNot yet recruiting
E-DA Hospital
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Kaohsiung CityTaiwanRecruiting
Taichung Veterans General Hospital
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TaichungTaiwanRecruiting
National Cheng Kung University Hospital
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TainanTaiwanRecruiting
National Taiwan University Hospital
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TaipeiTaiwanRecruiting
Taipei Medical University Hospital
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TaipeiTaiwanRecruiting
Taipei Veterans General Hospital
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TaipeiTaiwanRecruiting
Piedmont Healthcare
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AtlantaUnited StatesRecruiting
Dana-Farber Cancer Institute
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BostonUnited StatesRecruiting
University of Virginia Health System
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CharlottesvilleUnited StatesRecruiting
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ChattanoogaUnited StatesWithdrawn
Rush University Medical Center
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ChicagoUnited StatesRecruiting
University Hospitals Cleveland Medical Center*
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ClevelandUnited StatesRecruiting
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C
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ColumbusUnited StatesRecruiting
John B Amos Cancer Center
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ColumbusUnited StatesRecruiting
Shaw Cancer Center
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EdwardsUnited StatesRecruiting
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GainesvilleUnited StatesWithdrawn
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HoustonUnited StatesNot yet recruiting
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care building
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IrvineUnited StatesRecruiting
Perlmutter Cancer Center at NYU Langone Hospital - Long Island
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MineolaUnited StatesRecruiting
Tennessee Oncology
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NashvilleUnited StatesRecruiting
NYU Langone Health
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New YorkUnited StatesRecruiting
Weill Cornell Medical College
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New YorkUnited StatesRecruiting
University of California, Irvine (UCI) Health - UC Irvine Medical Center
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OrangeUnited StatesRecruiting
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Pembroke PinesUnited StatesNot yet recruiting
Hospital of the University of Pennsylvania
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PhiladelphiaUnited StatesRecruiting
West Penn Allegheny Health
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PittsburghUnited StatesRecruiting
Providence St. Vincent Medical Center
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PortlandUnited StatesRecruiting
Providence Cancer Institute Franz Clinic
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PortlandUnited StatesRecruiting
Oregon Health and Science University
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PortlandUnited StatesRecruiting
Renown Regional Medical Center
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RenoUnited StatesRecruiting
Virginia Commonwealth University (Vcu)
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RichmondUnited StatesRecruiting
Rochester General Hospital Infectious Disease
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RochesterUnited StatesRecruiting
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San AntonioUnited StatesNot yet recruiting
Washington University School of Medicine
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St LouisUnited StatesRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.