NCT07100691Not yet recruitingPhase 4
Gastric Emptying With Metoclopramide in GLP-1 Agonist Patients Undergoing Elective Surgery
Preoperative Metoclopramide to Enhance Gastric Emptying in Patients on Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss: A Randomised Controlled Trial With Ultrasound Assessment
Source: ClinicalTrials.gov · Last updated 6 Aug 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This is a multicentre, investigator-blinded, randomised controlled trial evaluating whether the use of oral metoclopramide before surgery can reduce the amount of residual gastric content in patients who are taking glucagon-like peptide-1 receptor agonists (GLP-1 RAs) for weight loss. These medications are known to slow down gastric emptying, which may increase the risk of pulmonary aspiration during anaesthesia. Patients will be randomly assigned to either receive metoclopramide 24 hours before surgery or continue with standard care. The primary outcome will be the presence or absence of residual gastric content on ultrasound before surgery. Secondary outcomes include nausea, vomiting, constipation, and any adverse effects of the medication.
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 80 (estimated)
- First submitted
- 27 Jul 2025
- Start date
- 1 Aug 2025
- Primary completion date
- 31 May 2026
- Lead sponsor
- Mater Misericordiae University Hospital
- Diseases
- Obesity
- NCT number
- NCT07100691
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 80
- From 1 Aug 2025 to the primary completion date, 31 May 2026
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Urgent or emergency surgery, including trauma
Other illness
- History of any gastric surgery
- Diagnosis of Parkinson's disease
- Allergy or intolerance to metoclopramide
Lab values
- Poorly controlled diabetes (HbA1c \>69 mmol/mol)
Other
- Inability to provide informed consent
- Presence of hiatus hernia
- Pregnancy
- Inability to lie in the right lateral decubitus position
- Patients taking chronic opioids
Who the study is looking for
- Patients taking GLP-1 receptor agonists (for weight loss only)
- Male and female patients aged 18 years or older
- Able to provide written informed consent
- ASA grade I-V
- Scheduled for elective surgery with an expected overnight hospital stay
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| National Orthopaedic Hospital Cappagh Coordinator of this site? Confirm its status | Dublin | Ireland | Unknown status |
| Rotunda hospital Coordinator of this site? Confirm its status | Dublin | Ireland | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.