NCT07101653Completed
Exercise-Induced Irisin and Brain Changes
From Muscle to Brain: Exercise Induces Structural Brain Changes, Irisin Elevation, and Functional Recovery in Multiple Sclerosis - Exploring the Interrelationships
Source: ClinicalTrials.gov · Last updated 3 Aug 2025
Brief summary (registry, in English)
This single-blind, randomized controlled trial will employ a two-arm parallel design (exercise group vs. control group) with a 12-week intervention period. Sex-stratified randomization will be implemented using SPSS 25.0 (IBM Corporation, Armonk, NY, USA) to ensure balanced group allocation. All outcome measures will be assessed at baseline and post-intervention.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 21 (actual)
- First submitted
- 21 Jul 2025
- Start date
- 15 Oct 2024
- Primary completion date
- 15 Nov 2024
- Lead sponsor
- Firat University
- Diseases
- Multiple sclerosis
- NCT number
- NCT07101653
What you commit to
- Study type: Interventional
- Participants enrolled: 21
- From 15 Oct 2024 to the primary completion date, 15 Nov 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Acute MS relapse within 90 days prior to enrollment
- Standard MRI contraindications (metallic implants, claustrophobia, etc.)
- Concurrent neurological disorders (other than MS)
Other illness
- Comorbid conditions that may limit exercise participation, including; significant orthopedic impairments, unstable cardiopulmonary conditions and other systemic disorders affecting physical activity
- Initiation or modification of disease-modifying therapy within 6 months
Other
- Regular participation in structured exercise programs (\>3 hours/week)
- Severe spasticity (Modified Ashworth Scale ≥3 in any major muscle group)
Who the study is looking for
- Clinically confirmed relapsing-remitting multiple sclerosis (RRMS) diagnosis according to revised McDonald criteria (2017)
- Aged 19-65 years (inclusive)
- Mild-to-moderate disability (EDSS score 1.0-5.5)
- No corticosteroid treatment within the previous 3 months
Age in the registry: 19 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Fırat university Coordinator of this site? Confirm its status | Elâzığ | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.