NCT07102693Completed
Left Atrial Strain Assessment in Ischemic Stroke Patients
Left Atrial Strain Assessment in Ischemic Stroke Patients: a Retrospective Case-control Study - the ASSISTANT Study
Source: ClinicalTrials.gov · Last updated 12 Aug 2025
Brief summary (registry, in English)
This study is investigating a potential link between a novel measurement made on cardiac ultrasound and the risk of ischemic stroke in patients with a normal heart rhythm. The novel measurement is called left atrial strain. It uses speckle tracking echocardiography to measure the muscle function of the left atrium, one of the cardiac chambers. Investigators investigated whether patients with lower function of this chamber are at a higher risk of developing stroke from blood clots traveling to the brain. It is already known that patients with an irregular heart rhythm known as atrial fibrillation are at higher risk of these types of strokes. Investigators wanted to determine if there is a similar association in patients with normal heart rhythm but low left atrial strain.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 468 (actual)
- First submitted
- 30 Jul 2025
- Start date
- 15 Jul 2024
- Primary completion date
- 1 Jun 2025
- Lead sponsor
- Connolly Hospital Blanchardstown
- Diseases
- Stroke
- NCT number
- NCT07102693
What you commit to
- Study type: Observational
- Participants enrolled: 468
- From 15 Jul 2024 to the primary completion date, 1 Jun 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Any history of atrial fibrillation prior or during admission
Age
- Age below 18 years of age
Other
- No echocardiogram or echocardiogram images not of sufficient quality to perform left atrial strain analysis
- At least moderate mitral regurgitation
- ASD or PFO
Who the study is looking for
- Emergency department presentation with FAST positive symptoms
- Neuroimaging performed as part of stroke workup
- Echocardiogram performed during index admission
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Connolly Hospital Blanchardstown Coordinator of this site? Confirm its status | Dublin | Ireland | Unknown status |
Related publications
- Impaired left atrial strain is associated with acute ischemic stroke in patients without atrial fibrillation.Front Stroke · 2026 · PMID 42523707
This page is information, not medical advice. Discuss any trial with your doctor.