NCT07103421Completed
Impact of Non Surgical Periodontal Therapy on Cystatin C Levels
Effect of Non-Surgical Periodontal Therapy on Cystatin C Levels in Healthy and Renal Impaired Patients
Source: ClinicalTrials.gov · Last updated 5 Aug 2025
Brief summary (registry, in English)
Study the effect of non-surgical periodontal therapy on cystatin C levels in gingival crevicular fluid and serum in both healthy patients and patients with renal impairment. The number of participants is 30 individuals, divided into three groups receiving conservative periodontal treatment (scaling and root planing):Systemically and periodontally healthy patients, Patients with periodontitis without systemic diseases, and Patients with periodontitis and chronic kidney disease. The study also aims to determine the relationship between the severity of periodontal disease and kidney function by measuring cystatin C levels, which is an important biomarker for both conditions. Additionally, it seeks to assess whether non-surgical periodontal therapy can be included in the treatment protocols for kidney patients to improve their quality of life.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 30 (actual)
- First submitted
- 24 Jul 2025
- Start date
- 12 May 2023
- Primary completion date
- 10 Jun 2024
- Lead sponsor
- Latakia University
- Diseases
- Chronic kidney disease
- NCT number
- NCT07103421
What you commit to
- Study type: Interventional
- Participants enrolled: 30
- From 12 May 2023 to the primary completion date, 10 Jun 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Grade C periodontal disease.
- Furcation involvement due to periodontal disease.
- Tooth loss due to periodontal disease.
Other
- \- Stage III or IV periodontitis.
- Bone loss in more than 10 sites.
- Pathological tooth mobility (Grade II or III).
- Heavy smoking (\>10 cigarettes/day).
- Pregnancy or lactation.
- Patients undergoing dialysis.
Who the study is looking for
- Patients with Stage II (Grade A or B) periodontitis (according to AAP 2017 classification).
- Age range: 20 to 70 years.
- No pathological tooth mobility.
- No furcation involvement caused by periodontal disease.
- No systemic diseases affecting periodontal or renal health.
- No systemic antibiotic use within the previous 3 months.
- No periodontal treatment within the previous 6 months
- For Chronic Kidney Disease (CKD) Patients:
- Confirmed CKD diagnosis for at least 3 years (by a consultant nephrologist).
- Receiving conservative management (pre-dialysis).
Age in the registry: 20 years to 70 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Tishreen University - faculty of Dentistry Coordinator of this site? Confirm its status | Latakia | Syria | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.