NCT07103603Completed
MHT and Liver Function in Postmenopausal Women
Effects of Menopausal Hormone Therapy on Liver Function and Non-Alcoholic Fatty Liver Disease: A Prospective Study
Source: ClinicalTrials.gov · Last updated 27 Jan 2026
Brief summary (registry, in English)
This prospective study aims to evaluate the effects of menopausal hormone therapy (MHT) on liver function, lipid profiles, and hepatic steatosis in postmenopausal women. A total of 44 participants will be divided into two groups: 22 received MHT and 22 were monitored without treatment. Biochemical parameters, FIB-4 scores, and attenuation imaging (ATI) measurements are assessed at baseline and after six months. The study investigates whether MHT is associated with favorable changes in liver enzymes, hepatic fat accumulation, and noninvasive fibrosis markers.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 44 (actual)
- First submitted
- 29 Jul 2025
- Start date
- 30 Oct 2024
- Primary completion date
- 30 Sept 2025
- Lead sponsor
- Ipek B. Ozcivit Erkan, MD
- Diseases
- Fatty liver disease (MASLD/MASH)
- NCT number
- NCT07103603
What you commit to
- Study type: Interventional
- Participants enrolled: 44
- From 30 Oct 2024 to the primary completion date, 30 Sept 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of medications known to affect liver enzymes or fat metabolism
Other illness
- History of liver disease, liver malignancy, or liver transplantation
- Premature ovarian failure
- History of any active malignancy
Other
- Current or past alcohol consumption exceeding 20g/day
- Current participation in another clinical trial
Who the study is looking for
- Female participants aged 40 years or older
- Postmenopausal status (defined as ≥12 months of amenorrhea)
- No prior use of menopausal hormone therapy in the last 6 months
- Willingness to participate and provide informed consent
Age in the registry: 40 years to - · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Istanbul University Cerrahpaşa - Cerrahpaşa Faculty of Medicine Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.