NCT07104630RecruitingPhase 2
Pulmonary Rehabilitation in Advanced Lung Cancer Survivors
Source: ClinicalTrials.gov · Last updated 22 Sept 2026
Brief summary (registry, in English)
This study is for people who have previously been diagnosed with advanced stage non-small cell lung cancer (NSCLC). Many people with advanced stage NSCLC have trouble breathing and feel tired. People may be eligible for this study if they have advanced stage NSCLC and feel short of breath some of the time. NSCLC survivors may also experience things like fatigue and a lower quality of life. Pulmonary rehabilitation is a type of supportive treatment that may improve these symptoms. This study has two parts. The first part is a randomized trial where half of the participants receive eight weeks of pulmonary rehabilitation. The other half of participants do not do pulmonary rehabilitation and instead receive the treatment that their doctors would normally recommend. The purpose of this part of the research study is to understand if pulmonary rehabilitation can help people with advanced stage NSCLC have better functioning and less shortness of breath. The other part of the research study is an interview study. The purpose of doing interviews is to understand any challenges or obstacles that people with advanced stage NSCLC may have regarding pulmonary rehabilitation, as well as oncology care providers have with their participants going to pulmonary rehabilitation.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 85 (estimated)
- First submitted
- 29 Jul 2025
- Start date
- 16 Mar 2026
- Primary completion date
- Dec 2026
- Lead sponsor
- Case Comprehensive Cancer Center
- Diseases
- Lung cancer
- NCT number
- NCT07104630
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 85
- From 16 Mar 2026 to the primary completion date, Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participants being treated with curative intent for locally advanced NSCLC or oligometastatic NSCLC with concurrent chemotherapy and radiation will be excluded
- Any of the following cardiac exclusion criteria:
- Class II, III or IV heart failure as defined by the New York Heart Association (NYHA) functional classification system
- History of acute coronary syndromes (including myocardial infarction and unstable angina), coronary angioplasty or stenting within the past 6 months prior to the start of radiation therapy
- Uncontrolled arrhythmias; individuals with rate-controlled atrial fibrillation for > 1 month prior to start of radiation therapy may be eligible
- Syncope
- Acute myocarditis, pericarditis, or endocarditis
- Acute pulmonary embolus or pulmonary infarction within the last 3 months
- Acute thrombosis of lower extremities within the last 3 months
- Suspected dissecting aneurysm
- Pulmonary edema
- Respiratory failure
- Acute non-cardiopulmonary disorder that may affect exercise performance or be aggravated by exercise
Other illness
- Mental impairment leading to inability to complete study requirements
Other
- Participants have evidence of clinical and/or radiographic progression
- High risk of fracture or spine instability (Mirels score ≥7 or SINS ≥7)
Who the study is looking for
- Participants must have histologically confirmed NSCLC, Stages III or IV treated with palliative intent
- Adults ≥ 18 years of age
- ECOG performance status ≤ 3
- Clinical stability: defined as no clinical/radiographic progression within the last three months
- Self-reported dyspnea, defined as score ≥ 2 on the modified Medical Research Council (mMRC) Dyspnea Scale
- Participants must be fluent in written and spoken English
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center Coordinator of this site? Confirm its status | Cleveland | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.