NCT07105397Recruiting
Evaluating Conversational Artificial Intelligence for Depression Management
Source: ClinicalTrials.gov · Last updated 9 Sept 2026
Brief summary (registry, in English)
The goal of this clinical trial is to evaluate how a conversational method of collecting medical history affects patients' perceptions and experiences compared to clinical care as usual. This conversational AI intake system collects medical history information, can be completed by participants at home, and do not disrupt routine clinical care. The primary questions this study aims to answer are: 1\) Does conversational intake affect patients' perceptions of empathy during their clinical interactions? This will be a prospective study that follows a cohort of participants for four (4) months after engaging with the AI intake system. Because each participant serves as his/her own control, both comparators will be administered within-subject, and the order of exposure (AI intake vs. usual care) will be randomized to minimize sequence effects. After completing the AI intake method, participants will rate their experience, particularly in terms of empathy and compare it to their usual interactions with their own clinicians.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 130 (estimated)
- First submitted
- 1 Jul 2025
- Start date
- 22 Jul 2026
- Primary completion date
- 15 Apr 2028
- Lead sponsor
- George Mason University
- Diseases
- Depression
- NCT number
- NCT07105397
What you commit to
- Study type: Interventional
- Planned participants: 130
- From 22 Jul 2026 to the primary completion date, 15 Apr 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Criteria the registry did not label
- Participant is between 18 to 85 years old.
- Participant has been, or are likely to be, diagnosed with moderate to severe Major Depressive Disorder without signs of bipolar depression.
- Participant is not in active suicidal crisis and do not face imminent risk of suicide within the next 3 hours.
- Participant is not pregnant or seeking to be pregnant.
- Participant able to communicate in English on the Internet.
- Participant must reside in the United States.
- Participant has access to a mental health clinician, or the participant is willing to see study clinicians to help review the advice and medication adjustments recommended by the AI Intake System to the participant.
- If the participant is seeing study clinicians, the participant must reside in a state where study clinicians are licensed.
- Participant must be using a device (phone or computer) that is located in the United States.
Age in the registry: 18 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| George Mason University Coordinator of this site? Confirm its status | Fairfax | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.