NCT07105553Completed
Glove Compression for Chemotherapy-Induced Neuropathy
Neuro Glove: A Prospective Self-Controlled Study of Glove Compression as a Protective Strategy Against Chemotherapy-Induced Peripheral Neuropathy in Women With Gynecologic Malignancies
Source: ClinicalTrials.gov · Last updated 6 Aug 2025
Brief summary (registry, in English)
This study investigates whether wearing tight-fitting surgical gloves on the non-dominant hand could help prevent chemotherapy-induced peripheral neuropathy (CIPN) in women with gynecologic cancers treated with paclitaxel. In this prospective, self-controlled observational study, seventy-six patients wear two tight surgical gloves on their non-dominant hand during each paclitaxel infusion. The dominant hand, without gloves, serves as a control. Neuropathy symptoms are assessed using the EORTC QLQ-CIPN20 questionnaire at baseline, mid-treatment, and end of treatment. Electromyography (EMG) is performed if clinically indicated.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 76 (actual)
- First submitted
- 13 Jul 2025
- Start date
- 1 Jan 2024
- Primary completion date
- 1 Jan 2025
- Lead sponsor
- Ankara Etlik City Hospital
- Diseases
- Endometrial cancer, Ovarian cancer
- NCT number
- NCT07105553
What you commit to
- Study type: Interventional
- Participants enrolled: 76
- From 1 Jan 2024 to the primary completion date, 1 Jan 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients receiving neoadjuvant chemotherapy with planned surgery
- Patients receiving weekly (dose-dense) paclitaxel regimens
- Prior exposure to neurotoxic chemotherapy agents (e.g., taxanes, platinum compounds, proteasome inhibitors, anti-tubulin agents)
- Concurrent use of medications that may mask or modulate neuropathy symptoms (e.g., gabapentinoids, SNRIs, vitamin B complex, alpha-lipoic acid)
Other illness
- History of pre-existing peripheral neuropathy
- Known allergy to latex or surgical gloves
- Diagnosed peripheral vascular disease
- Clinical diagnosis of diabetic neuropathy or history of alcohol-related neuropathy
- Raynaud's phenomenon or other cold-sensitive vascular conditions
- Other neurological disorders that may interfere with neuropathy assessment
Other
- Refusal or inability to provide informed consent
Who the study is looking for
- Female patients aged ≥18 years
- Histologically confirmed gynecologic malignancy (e.g., ovarian, or endometrial cancer)
- Scheduled to receive carboplatin-paclitaxel chemotherapy administered every 21 days
- Planned for a total of six chemotherapy cycles
- ECOG performance status 0-2
- Ability to provide written informed consent
Age in the registry: 18 years to - · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Etlik City Hospital Coordinator of this site? Confirm its status | Ankara | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.