NCT07107152Completed
Effect of Static vs. Conversational AI-Generated Messages on Colorectal Cancer Screening Intent: a Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 7 Aug 2025
Brief summary (registry, in English)
The goal of this clinical trial is to assess whether messages generated by a large language model (LLM), including both static and conversational formats, can increase colorectal cancer (CRC) screening intentions among U.S. adults aged 45-75 who have never completed CRC screening. The main questions it aims to answer are: Do personalized, AI-generated messages increase the self-reported likelihood of completing a stool-based CRC screening test within 12 months? Do they also increase intent to undergo colonoscopy screening within 12 months? Researchers will compare four groups: (1) no message control, (2) expert-written patient education materials, (3) a single AI-generated persuasive message, and (4) a motivational interviewing-style AI chatbot. These comparisons will help assess whether a conversational format offers added benefit over static AI or expert-generated content. Participants will: Be randomly assigned to one of the four study arms Spend at least 3 minutes reading or interacting with their assigned material Complete pre- and post-intervention surveys assessing intent to receive CRC screening Receive messages tailored to their self-reported demographics, including age, political ideology, gender, education, community setting (urban, rural, suburb), self-reported health, and the last time they saw their PCP
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 915 (actual)
- First submitted
- 30 Jul 2025
- Start date
- 11 Jun 2025
- Primary completion date
- 21 Jun 2025
- Lead sponsor
- University of Pennsylvania
- Diseases
- Colorectal cancer
- NCT number
- NCT07107152
What you commit to
- Study type: Interventional
- Participants enrolled: 915
- From 11 Jun 2025 to the primary completion date, 21 Jun 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous colonoscopy, stool test, sigmoidoscopy, or CT colonography
Other illness
- Failure to pass pre- or post-intervention attention checks
Other
- Identified as non-human respondents by reCAPTCHA or other automated bot detection
- Completion time significantly shorter than the median, indicating inattentiveness
Who the study is looking for
- Adults aged 45 to 75 years
- Currently residing in the United States
- Self-reported no prior colorectal cancer screening (or unsure if screened)
- Able to read and understand English
- Consent to participate in a behavioral research study
Age in the registry: 45 years to 75 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Participants are recruited online via Prolific Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.