NCT07108595Completed
Efficacy and Safety of T-DXd in Patients With HER2-positive and HER2-low Metastatic Breast Cancer: a Real-world Study
Source: ClinicalTrials.gov · Last updated 7 Aug 2025
Brief summary (registry, in English)
Evaluate the efficacy and safety of T-DXd in patients with HER2-positive and HER2-low metastatic breast cancer
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 142 (actual)
- First submitted
- 31 Jul 2025
- Start date
- 1 Jan 2021
- Primary completion date
- 31 Aug 2024
- Lead sponsor
- The First Affiliated Hospital with Nanjing Medical University
- Diseases
- Metastatic breast cancer
- NCT number
- NCT07108595
What you commit to
- Study type: Observational
- Participants enrolled: 142
- From 1 Jan 2021 to the primary completion date, 31 Aug 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- concurrent malignancies;
Other illness
- history of interstitial lung disease
- psychiatric disorders compromising treatment adherence
Other
- incomplete medical records
- pregnancy or lactation
Who the study is looking for
- female patients aged ≥18 years;
- histologically confirmed HER2-positive (IHC 3+ or IHC 2+/FISH+) or HER2-low (IHC 1+ or IHC 2+/FISH-) disease;
- radiologically confirmed recurrent or metastatic disease;
- completion of ≥2 cycles of T-DXd therapy;
- comprehensive medical documentation;
- Eastern Cooperative Oncology Group (ECOG) performance status ≤3;
- measurable target lesions according to RECIST 1.1
Age in the registry: 18 years to 85 years · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Jiangsu Provincial People's Hospital, Nanjing, JiangSu 210000 Coordinator of this site? Confirm its status | Nanjing | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.