NCT07111260Recruiting
Efficacy of pHA130 Hemoadsorption for 4 Hours (p4H Study)
Comparison of the Efficacy of Hemoadsorption Combined With Hemodialysis of Different Treatment Durations in Clearing Protein-Bound Uremic Toxins: A Randomized Crossover Controlled Trial
Source: ClinicalTrials.gov · Last updated 8 Aug 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This is an open-label, randomized, crossover study to evaluate the efficacy of extending the duration of hemoadsorption (HA) combined with hemodialysis (HD) from 2 hours to 4 hours for clearing protein-bound uremic toxins, such as Indoxyl Sulfate (IS), in stable maintenance hemodialysis patients. Patients will be randomized to receive either 2-hour HA or 4-hour HA once a week for 8 weeks, then cross over to the other treatment for another 8 weeks after a 2-week washout period. The primary endpoint is the reduction rate of IS.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 34 (estimated)
- First submitted
- 28 Jul 2025
- Start date
- 1 Jul 2025
- Primary completion date
- Mar 2026
- Lead sponsor
- Peking University People's Hospital
- Diseases
- Chronic kidney disease
- NCT number
- NCT07111260
What you commit to
- Study type: Interventional
- Planned participants: 34
- From 1 Jul 2025 to the primary completion date, Mar 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Active or chronic gastrointestinal bleeding, or diagnosed coagulation disorders
- Active malignant tumor
- Active infection
Lab values
- White blood cell count \< 4 × 10⁹/L and/or platelet count \< 60 × 10⁹/L
Other
- Life expectancy less than 1 year
- Pregnant or breastfeeding
- Participation in another clinical trial within the past month or currently enrolled in one
- Deemed unsuitable for the study by the investigator
Who the study is looking for
- Age between 18 and 75 years, regardless of gender
- Stable maintenance hemodialysis for ≥3 months, with a relatively fixed dialysis regimen
- Receiving hemodialysis 3 times per week, each session lasting ≥4 hours
- Single-pool Kt/V (spKt/V) ≥1.2 within 8 weeks prior to enrollment
- Willing and able to sign the informed consent form
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Peking University People's Hospital Coordinator of this site? Confirm its status | Beijing | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.