NCT07112248Completed
Effects of Soluble Fiber Supplements on Sperm Quality in Males With Obesity: a Randomized Trial
A Randomized Controlled Trial Investigating the Effects of Soluble Dietary Fiber Supplements on Sperm Quality Parameters in Males With Obesity
Source: ClinicalTrials.gov · Last updated 18 May 2026
Brief summary (registry, in English)
Obesity-related poor sperm quality is a significant public health issue, acting as a major contributor to male infertility. Dietary intervention has emerged as an effective strategy to manage obesity and improve sperm quality. Soluble dietary fiber (SDF), an essential nutritional component, plays a crucial role in regulating host health. Notably, insufficient SDF intake has been associated with both obesity and low sperm motility. However, the effect of SDF supplementation on sperm quality in males with obesity remains unclear. Thus, we conducted a randomized, placebo-controlled study to investigate the effect of SDF supplementation on sperm quality in males with obesity.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 74 (actual)
- First submitted
- 2 Aug 2025
- Start date
- 10 Aug 2025
- Primary completion date
- 4 Jan 2026
- Lead sponsor
- Huazhong University of Science and Technology
- Diseases
- Obesity
- NCT number
- NCT07112248
What you commit to
- Study type: Interventional
- Participants enrolled: 74
- From 10 Aug 2025 to the primary completion date, 4 Jan 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Recent usage of medications/supplements affecting spermatogenesis or gut microbiota ;
Other illness
- Severe systemic diseases such as cardiovascular/cerebrovascular, hepatic/renal disorders, malignant tumors, uncontrolled diabetes, or thyroid diseases;
- Lifestyle factors potentially impairing sperm quality or severe gastrointestinal disorders;
- Poor compliance, planned imminent fertility, or history of bariatric surgery/weight-loss medications;
Other
- Spermatogenic dysfunction caused by non-obesity factors;
- Significant dietary changes within the past three months.
Who the study is looking for
- Male, aged 18-60 years；
- Diagnostic criteria for obesity: BMI ≥ 28 kg/m² and body fat percentage ≥ 25%;
- Semen samples can be collected, and sperm concentration \> 0.
Age in the registry: 18 years to 60 years · Sex: Male · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hubei Maternal and Child Health Care Hospital Coordinator of this site? Confirm its status | Wuhan | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.