NCT07112456RecruitingPhase 2
Nebulized Ketamine Plus Standard Care vs. Standard Care Alone in Moderate to Severe Asthma Exacerbations
Nebulized Ketamine Plus Standard Care vs. Standard Care Alone in Moderate to Severe Asthma Exacerbations: A Randomized Clinical Trial (KET-AIR Trial)
Source: ClinicalTrials.gov · Last updated 19 Oct 2026
Brief summary (registry, in English)
The goal of this clinical trial is to learn if nebulized ketamine helps treat moderate to severe asthma attacks in adults in the emergency department. It will also learn about the safety of ketamine when inhaled through a nebulizer. The main questions it aims to answer are: * Does nebulized ketamine improve breathing more than standard treatment alone? * What side effects, if any, do participants experience after receiving nebulized ketamine? Researchers will compare nebulized ketamine to a placebo (a saltwater mist with no medication) to see how well it works and how safe it is. Participants will: * Receive either nebulized ketamine or a placebo mist, along with standard asthma treatment * Have their breathing checked before and after treatment using a peak flow meter * Be monitored for 60 minutes and have their symptoms, vital signs, and any side effects recorded
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 100 (estimated)
- First submitted
- 22 Jul 2025
- Start date
- May 2026
- Primary completion date
- Aug 2029
- Lead sponsor
- Oman Medical Speciality Board
- Diseases
- Asthma
- NCT number
- NCT07112456
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 100
- From May 2026 to the primary completion date, Aug 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Known hypersensitivity or allergy to ketamine or any component of the nebulized solution.
- History of psychosis, schizophrenia, or other severe uncontrolled psychiatric disorders.
- Uncontrolled hypertension, defined as systolic BP \> 180 mmHg or diastolic BP \> 110 mmHg on two consecutive readings at least 5 minutes apart, despite initial ED management.
- Significant chronic lung disease, including:
- COPD with frequent exacerbations or baseline FEV₁ \< 50% predicted
- Interstitial lung disease (ILD)
- Clinically significant bronchiectasis with baseline productive cough or infection
- Severe cardiac disease, including decompensated heart failure, recent myocardial infarction (\<6 weeks), or known severe valvular disease.
- Any other medical, surgical, or psychiatric condition that in the opinion of the investigator would place the patient at undue risk from study participation or interfere with the interpretation of study results.
Other
- Hemodynamic instability, including persistent hypotension (SBP \< 90 mmHg) or tachyarrhythmias requiring urgent treatment.
- Pregnancy or currently breastfeeding.
- Home BiPAP use or requirement for non-invasive ventilation (e.g., BiPAP/CPAP) during the ED visit (Note: isolated home CPAP for sleep apnea without daytime symptoms is acceptable).
- Current intubation or imminent need for mechanical ventilation based on clinical judgment.
Who the study is looking for
- Adults aged 18 years or older presenting to the Emergency Department with a clinical diagnosis of moderate to severe asthma exacerbation based on SIGN (Scottish Intercollegiate Guidelines Network) criteria.
- PEFR between 33% and 75% of predicted value or personal best, as measured using a peak flow meter.
- Stable vital signs as deemed by the treating physician
- Alert and oriented, able to understand the study purpose and provide informed consent.
- Not requiring immediate advanced airway intervention, including intubation or emergency non-invasive ventilation.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Sultan Qaboos University Hospital Coordinator of this site? Confirm its status | Muscat | Oman | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.