NCT07115628Recruiting
Accelerated TMS for Treatment-Resistant ECT
Accelerated dTMS Treatment for ECT-non Responders
Source: ClinicalTrials.gov · Last updated 11 Aug 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This study investigates whether an additional treatment using transcranial magnetic stimulation (TMS) can help severely depressed patients who did not respond well to electroconvulsive therapy (ECT). All participants will first receive standard ECT treatment for depression, including brain scans (fMRI), psychological testing, clinical assessments, and the collection of blood and stool samples. If the ECT treatment is not effective, patients will be invited to participate in a second part of the study where they receive a 4-day course of accelerated TMS (20 sessions in total). The study aims to assess whether this additional TMS treatment can reduce depressive symptoms. The study also explores how brain structure, genetics, and gut health may relate to treatment success. In total, 200 patients will be included.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 200 (estimated)
- First submitted
- 30 Jul 2025
- Start date
- Oct 2025
- Primary completion date
- Dec 2027
- Lead sponsor
- Universitair Ziekenhuis Brussel
- Diseases
- Depression
- NCT number
- NCT07115628
What you commit to
- Study type: Interventional
- Planned participants: 200
- From Oct 2025 to the primary completion date, Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- A personal history of seizures or epilepsy, a history of seizures or epilepsy in first degree relatives and the presence of any known factor that can lower the seizure threshold (sleep deprivation, abuse substance, etc.), previous head injury and the presence of metallic implants in the cephalic region (e.g., aneurysm clips, shunts, stimulators, cochlear implants, electrodes) except dental fill-ings and the presence of cardiac pacemakers, neurostimulators, surgical clips or other electronic equipment, comorbidity with some neurological disorders: increased intracranial pressure, space-occupying lesion, history of stroke or transient ischemic attack, brain aneurysm and any structural brain damage with increased risk for epilepsy detected with MRI
- Suicide attempt within 6 months before the start of the study or pre-sent risk of suicide per the investigator's clinical judgment
Other illness
- Patients with cognitive disturbances or dementia (Mini Mental State) \< 24
Who the study is looking for
- Diagnosis of Major Depressive Disorder (MDD)
- Age between 18 - 70 years
- Referred for ECT treatment
Age in the registry: 18 years to 70 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UZ Brussel Coordinator of this site? Confirm its status | Jette | Belgium | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.