NCT07117084Active, not recruiting
Imaging Markers of High-Risk Plaque Phenotype for Predicting Post-PCI Outcomes
Imaging Markers of High-Risk Plaque Phenotype for Predicting Post-PCI Outcomes (IMPACT-PCI) Study: A Multicenter Cohort Study Based on Coronary CT Angiography
Source: ClinicalTrials.gov · Last updated 12 Aug 2025
Brief summary (registry, in English)
Despite the widespread use of stents, previous studies have shown that stent implantation mainly relieves symptoms but may not significantly improve long-term outcomes in patients with stable coronary artery disease. Identifying the types of plaques that are most likely to benefit from stenting is essential for improving personalized treatment. This study explores whether coronary computed tomography angiography (CCTA)-derived imaging biomarkers of coronary plaques are associated with increased risk of adverse outcomes after percutaneous coronary intervention (PCI). Around 2,000 patients who underwent CCTA followed by stent placement were included. Advanced software was used to quantify plaque inflammation and composition. Findings from this research may help guide personalized treatment strategies in patients undergoing PCI.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 2000 (estimated)
- First submitted
- 5 Aug 2025
- Start date
- 1 Jan 2021
- Primary completion date
- 31 Dec 2024
- Lead sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
- Diseases
- Coronary artery disease
- NCT number
- NCT07117084
What you commit to
- Study type: Observational
- Planned participants: 2000
- From 1 Jan 2021 to the primary completion date, 31 Dec 2024
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- elevated cardiac troponin levels within the 3 months preceding PCI;
- history of coronary artery bypass grafting;
- heart failure;
- significant valvular heart disease;
- refractory hypertension;
Other
- patients whose PCI within 30 days after CCTA was performed on an emergency basis;
- inadequate CCTA image quality;
- balloon-only or mixed stent/balloon PCI strategies;
- PCI for non-atherosclerotic lesions (e.g., in-stent restenosis, spontaneous coronary dissection);
- non-ischemic cardiomyopathy;
- persistent atrial fibrillation.
Who the study is looking for
- patients aged 18 years or older;
- patients who underwent clinically indicated PCI within 30 days following CCTA;
- CCTA demonstrating the presence of coronary atherosclerotic plaque.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Fuwai Hospital Chinese Academy of Medical Sciences Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
| Tai'an Central Hospital Coordinator of this site? Confirm its status | Tai’an | China | Unknown status |
| Weifang People's Hospital Coordinator of this site? Confirm its status | Weifang | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.