NCT07118514Completed
Effect of Resistance Training on Psychophysiological Indicators in People With Multiple Sclerosis
Effects of a Resistance Training Program on Immunological, Psychological, and Functional Indicators in People With Multiple Sclerosis: A Randomized Clinical Trial
Source: ClinicalTrials.gov · Last updated 19 Aug 2025
Brief summary (registry, in English)
This randomized controlled trial aims to investigate the effects of a supervised resistance training program on plasma levels of Brain-Derived Neurotrophic Factor (BDNF) and irisin in individuals diagnosed with multiple sclerosis (MS). The study will also examine secondary outcomes, including fatigue, quality of life, anxiety and depression symptoms, muscular strength, and functional capacity. Participants will be randomly assigned to either an intervention or control group in a 2:1 allocation ratio. The intervention group will undergo a 12-week supervised resistance training program, while the control group will maintain their usual care without engaging in any structured exercise regimen. The trial will be non-blinded and involve assessments at baseline and after the 12-week intervention period. Eligible participants must be adults (≥18 years), of any sex, with a confirmed diagnosis of MS by a neurologist, and currently undergoing disease-modifying therapy (DMT). Participants must not be engaged in any other structured physical exercise program, though symptom-management physiotherapy will be permitted. All participants should have sufficient mobility to complete the training sessions and assessments. Exclusion criteria include the inability to perform the physical training or functional tests due to severe mobility restrictions, lack of standard pharmacological treatment for MS, or concurrent participation in other structured exercise programs.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 40 (actual)
- First submitted
- 5 Aug 2025
- Start date
- 15 Aug 2024
- Primary completion date
- 17 Dec 2024
- Lead sponsor
- State University of Maringá
- Diseases
- Multiple sclerosis
- NCT number
- NCT07118514
What you commit to
- Study type: Interventional
- Participants enrolled: 40
- From 15 Aug 2024 to the primary completion date, 17 Dec 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Severe musculoskeletal conditions contraindicating exercise
- Any other condition that, in the opinion of the research team, may interfere with participation or compromise data integrity
Other
- Pregnancy or planning to become pregnant during the study period
- Participation in another structured or systematic exercise program
- Visual, cognitive, or communication impairments that may hinder participation
- Use of orthopedic devices incompatible with the intervention protocols
Who the study is looking for
- Confirmed diagnosis of Multiple Sclerosis (MS) according to the 2017 McDonald Criteria
- Expanded Disability Status Scale (EDSS) score between 1.0 and 6.0
- Age between 18 and 60 years
- Medical clearance to engage in physical exercise
- Ability to understand and provide written informed consent
- Stable pharmacological treatment for MS for at least 3 months prior to enrollment
- No MS relapses or corticosteroid use within 30 days before starting the intervention
Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| State University of Maringá Coordinator of this site? Confirm its status | Maringá | Brazil | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.