NCT07119957Recruiting
ProspEXPO : Study of the Associations Between Hepatocellular Carcinoma and Chemical and Psychosocial Environmental EXPOsome
ProspEXPO : PROSPective Study of the Associations Between Hepatocellular Carcinoma and Chemical and Psychosocial Environmental EXPOsome
Source: ClinicalTrials.gov · Last updated 10 Jun 2026
Brief summary (registry, in English)
The aim of the study is to build up a bio-collection of biological samples from patients with cirrhosis. Further work using this bio-collection will permit to describe the influence of different exposome factors (nutrition, physical activity, socio-demographic conditions, tobacco, alcohol, pollutants) on the occurrence of the main type of liver cancer (called HCC). Indeed, in the vast majority of cases, HCC develops within cirrhosis, and the factors that precipitate the progression of cirrhotic patients to HCC remain largely unknown.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 300 (estimated)
- First submitted
- 9 Jul 2025
- Start date
- 17 Dec 2025
- Primary completion date
- Dec 2028
- Lead sponsor
- University Hospital, Angers
- Diseases
- Liver and biliary tract cancer
- NCT number
- NCT07119957
What you commit to
- Study type: Interventional
- Planned participants: 300
- From 17 Dec 2025 to the primary completion date, Dec 2028
- 4 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Decompensation of cirrhosis in the two years prior to inclusion (ascites, hepatic encephalopathy, gastrointestinal variceal hemorrhage, liver failure, hepatorenal syndrome)
Other illness
- Causes of chronic liver disease other than MASLD, ALD, or MetALD
- For the "Control" group: history of hepatocellular carcinoma
Other
- Pregnant, breast-feeding or parturient women
- Persons deprived of liberty by judicial or administrative decision
Who the study is looking for
- Presence of metabolic and/or alcoholic steatotic liver disease, as defined by the new nomenclature (MASLD, ALD, or mixed MetALD)
- Liver biopsy performed (less than 2 months ago) or planned as part of treatment for diagnosis of cirrhosis ("Control" group without HCC) or diagnosis of HCC on cirrhosis ("Case" group)
- Patient affiliated to or benefiting from a social security scheme
- Patient having signed an informed consent to participate in the study (bio-collection)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Angers University Hospital Coordinator of this site? Confirm its status | Angers | France | Recruiting |
| Rennes University Hospital, Hepatogastroenteroly Department Coordinator of this site? Confirm its status | Rennes | France | Not yet recruiting |
| Centre Eugène Marquis (Oncology center) Coordinator of this site? Confirm its status | Rennes | France | Not yet recruiting |
| Tours University Hospital, HepatoGastroenterology Department Coordinator of this site? Confirm its status | Tours | France | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.